Tesamorelin | Review of Benefits, Dosage, Side Effects, and More

tesamorelin review

Titus Thorne Titus Thorne

Last Updated May 4, 2021

You’ve heard about Tesamorelin benefits.

Now, you're looking for a comprehensive Tesamorelin review — including benefits, dosage, side effects, and more?

Well, you’ve come to the right place.

Tesamorelin was originally developed by a Canadian company to treat a condition that is common in patients with HIV. These patients were taking HIV antiretroviral therapy, where body fat begins to accumulate in the abdomen.

Tesamorelin has been found to be very effective for that use, substantially reducing body fat.

But since it also mimics your body’s own, natural growth hormone-releasing hormones, users report that Tesamorelin benefits, more generally, include the benefits of growth hormone itself:

Increased muscle mass. Faster recovery times. Better body composition

In this article, we’re bringing to you a full Tesamorelin review — so you understand what it is and how it works. As always, talk to your doctor before starting any peptide regimen.

Buy Tesamorelin from the #1 online Peptides vendor in the world: Peptides Sciences

P.S: This is not medical or legal advice. This is strictly for entertainment purposes. We are not doctors - nor lawyers. All information below is presented for use on "test subjects" only. Not for human consumption. Please read my disclaimer.

What is Tesamorelin?

Tesamorelin acetate, known less formally as Tesamorelin and by its brand name Egrifta, is a synthetic peptide hormone. Peptides are chains of amino acids—the substances that make up proteins. They’re basically small proteins that do not have the 3D shape that proteins have.

Tesamorelin is also a hormone, which means that it interacts with the endocrine system in your body. It sends chemical signals to your body to help regulate functioning.

More specifically, Tesamorelin peptide is a synthetically made copy of your body’s naturally made growth hormone-releasing hormone (GHRH). Tesamorelin is one of a family of GHRH secretagogues; peptides that cause your body to produce and release its own growth hormone.

Others include Sermorelin and Ipamorelin. Each of these work by binding to certain receptors in your body that send a signal to your pituitary gland to release growth hormone.

Why does growth hormone (GH) matter?

Well, it’s one of the most important chemical signals for your body to build and repair tissue. It’s involved in all processes from creating new muscle, repairing torn tissue, and even breaking down fat. The more growth hormone you have in your body, the faster your body can repair and regenerate itself.

Because of its role in creating new tissue, GH is plentiful in your body when you’re young. Children and young adults have especially high levels of GH.

However, once you get past your 30s, there starts to be a steady decline in GH levels. That’s one of the reasons that you feel much more tired and your body has more difficulty recovering when you’re older.

Tesamorelin and other GHRHs address this by signaling the pituitary gland to produce more HGH so that the levels of GH in the body go back to what they were when the patient was younger. Users report that they feel younger. They put on muscle more quickly, lose body fat, recover from workouts quicker, and generally feel like they have much more energy.

Tesamorelin is made up of a chain of 44 amino acids as well as a trans-3-hexenoic acid group [1]. The extra trans-3-hexenoic acid group has been found to make Tesamorelin more stable and also more powerful than natural GHRH, although it has the same effect. That’s why some people have said that Tesamorelin and the effects of it last longer than Sermorelin, Ipamorelin, and CJC-1295.

Tesamorelin was originally developed by a Canadian company called Theratechnologies, inc [2], but now several companies produce and sell the peptide, including some American companies like Peptide Sciences.


Does Tesamorelin Actually Work?

Well, there are certainly lots of users on the internet claiming that it does.

One user on Reddit [3] has said, “Tesamorelin HGH absolutely incinerates visceral fat. My protocol was 1g a night with 150mg ipam, for 5 weeks. Expensive but if you want to be shredded and diced in the midsection, it’s well worth the cost. Of course diet and exercise play an important role but this accelerates the process.”

Not that this user probably means 1 mg a night with 150 mcg Ipamorelin; 1 g is a very, very high dosage (see Tesamorelin dosage section for more details). Still, the results are consistent with what we’ve heard from many other users.

Others, including doctors for athletes, suggest that it’s great for reducing fat and improving sleep. Some have even reported that it has helped their cognitive function, and may do this to an especially large effect in populations of older individuals.

Here’s a collection of the user-reported benefits of Tesamorelin HGH that we’ve found online [3]:

  • Reduc​e bo​dy fat
  • Increase muscle mass building capability
  • Increase systemic growth hormone
  • Decreases carotid artery plaque
  • Improves sleep quality

Is Tesamorelin Legal?

Based on the results from users, you may be asking yourself: is Tesamorelin legal?

Yes, it is.

Tesamorelin is legal to use in the United States. It was approved by the US Food and Drug Administration in 2010 and indicated to address lipodystrophy, especially for individuals who have HIV and are taking HIV medications [1].

It is currently not approved as a diet supplement or for cosmetic use. However, researchers can buy Tesamorelin legally online from reputable sources like Peptide Sciences.

Tesamorelin Before and After

What is the effect of Tesamorelin before and after?

The effect is mostly on body fat. Tesamorelin acts like a furnace, revving up the metabolism and burning up fat, especially visceral body fat (which is fat around the organs). Users report that Tesamorelin is a super effective way to add on to the benefits of a balanced diet and regular exercise to change body composition.

Because it increases growth hormones, users also report that Tesamorelin increases the ability of the body to respond to injuries and also build muscle. This combined effect is why so many users try Tesamorelin bodybuilding.

Tesamorelin Benefits and Uses

Great, so people on Reddit like Tesamorelin… but what does the research say about it?

Actually, there’s been lots of research on Tesamorelin, partly due to the fact that it’s approved by the FDA. So we know quite a bit about it. Here’s what the research says about how Tesamorelin benefits “test subjects” and how it can be used.

Increasing growth hormone

Tesamorelin has been found to be very effective at increasing growth hormone levels in the body [4]. Because it does that, the body is better prepared to build new tissue and repair it. The benefits of higher levels of growth hormone are many, and they include:

  • Increases in muscle mass
  • Increases in collagen production, which results in thicker, smoother, younger-looking skin
  • Better sleep
  • Higher bone density and healthier bones

Fat loss

One of the primary uses of Tesamorelin is to treat Lipodystrophy that occurs in individuals who have contracted HIV. Lipodystrophy is a condition of the metabolism that’s characterized by resistance to insulin [2]. While its cause is not yet clear, there could be something in the antiretroviral therapy drugs that people with HIV take that changes the way fat is broken down and stored in the body. That means that their bodies cannot break down fat properly.

One of the results of lipodystrophy is redistribution of body fat and hyperlipidemia, with fat accumulating in the upper back and stomach [2]. This increase in body fat can cause body image issues as well as increase the risk of heart attack and other cardiovascular diseases.

Tesamorelin seems to be an effective treatment for this condition. In HIV-infected patients with lipodystrophy and excess body fat around the abdomen, Tesamorelin was found to significantly decrease subcutaneous adipose tissue (body fat) by 15% [5]. In contrast, the control group participants had a 5% increase in body fat. It was also found to improve insulin resistance and cholesterol.

More importantly, patients’ scores on body image improved significantly in the Tesamorelin group: they found that “test subjects” perceived their bodies as more attractive following treatment [5].

These results are not isolated; they’ve been confirmed by a review of 4 randomized controlled trials [6]. The research suggests that Tesamorelin is actually 4 times more effective in reducing adipose tissue (body fat) than all other treatments combined [7].

Cardiac disease

There is also some suggestion that Tesamorelin could play a role in improving outcomes for patients with HIV-linked cardiovascular disease. It’s been found to reduce triglycerides in the blood and also reduces total cholesterol levels. These both are great for people that are at higher risk of cardiac disease [5].

Nerve Damage

Injury, surgery, and even diabetes can cause peripheral nerve damage and result in the loss of motor and sensory function in various parts of the body. Typically, there is very little that can be done about this; nerve cells are very difficult to regenerate.

Some research has shown, though, that Tesamorelin and other GHRH secretagogues may actually be able to improve the extent to which nerves can regenerate themselves. Tesamorelin is currently being tested for this and is one of the more promising treatment options [8]


There is also some promising research about the role that GHRH analogs, including Tesamorelin, may play in improving cognitive function for individuals in the beginning stages of dementia.

A large control trial out of Washington found evidence that Tesamorelin may increase levels of some neurotransmitters in the brain that are associated with better cognitive function [9]. More research is needed to confirm these findings.

Tesamorelin Side Effects

Adverse side effects are rare with Tesamorelin, but as with most peptides, there is a possibility of side effects. The risk of Tesamorelin side effects increases with the amount of Tesamorelin dosage.

Some of the more commonly reported side effects include the following (reported in about 2.2% of users [5]:

  • redness, itching, pain, swelling, and irritation at the site of injection
  • muscle aches
  • diarrhea
  • sweating

Less common but more serious side effects include:

  • neuropathies
  • diarrhea with fever and dehydration
  • congestive heart failure
  • shortness of breath
  • muscle or joint pain
  • numbness, tingling, swelling in arms or legs

One side effect of Tesamorelin is that it may cause glucose intolerance and increase the risk of type 2 diabetes mellitus. If you already suffer from diabetes, this is probably not the peptide for you.

It’s also not good for you if you are pregnant because there is a possibility that it could cause harm to the fetus [2].

There is a possibility of allergic reactions to all medications. If you experience any persisting or serious side effects, contact your doctor or pharmacist.

Tesamorelin Dosage Guide

Tesamorelin, like all drugs, should be used on the guidance of a qualified health professional. Your doctor or pharmacist will be able to help you use Tesamorelin properly and at the right dose.

How to Use Tesamorelin

To use Tesamorelin, follow the directions provided by your health professional and on the box. Here is a brief step-by-step guide to using tesamorelin:

  1. First, wash your hands with soap and water to avoid infection
  2. Tesamorelin usually comes in a powder form in a vial. You need to reconstitute it by adding bacteriostatic water. Follow the instructions with your product to reconstitute it. Usually, you do this by injecting bacteriostatic water in the vial and then gently swirling the vial until the contents are completely dissolved.
  3. Inspect the product to ensure there are no particles or discoloration in the solution. If there are, do not use it.
  4. Inject the medication under the skin on your stomach. Choose an area below the belly button. Avoid areas with scar tissue, bruises, redness, or irritation. Clean the area with rubbing alcohol before injection.
  5. Change the site of injection each time to reduce skin injury

Tesamorelin Dosage for Lipodystrophy and Fat Loss

For patients with lipodystrophy as a result of contracting HIV, it’s recommended that Tesamorelin dosage is [2]:

  • 1 daily, subcutaneous injection
  • Tesamorelin dosage of 2 milligrams (mg)
  • at the same time each day.
  • 5 days a week

Food does not seem to interfere with Tesamorelin benefits so a normal diet can be used with it (although, the healthier the diet, the better the effects will be for body composition improvements). Ideally, Tesamorelin should be taken at least 90 minutes after eating and before bedtime.

Tesamorelin Bodybuilding Dosage

There’s not much research on the dosage for Tesamorelin bodybuilding, but some doctors have suggested that 1 mg per day could be useful for athletes [10]:

  • 1 daily, subcutaneous injection
  • Tesamorelin dosage of 1 mg
  • At night before bed
  • 5 days a week

One user has recommended that it’s best used in combination with a GHRP like Ipamorelin that reduces somatostatin, which is an inhibitor of GH [10]. Ipamorelin helps ensure the release of GH that Tesamorelin creates. You can add 100 mcg of Ipamorelin, twice a day: by itself in the morning and together with the Tesamorelin at night.

As always, you should take advice from your doctor when using any peptide.

Where to Buy Tesamorelin Online? | 2021 Guide

Tesamorelin is legally available for researchers to buy online.

You just need to be sure that you’re getting a high-quality, pure product for your “test subjects”. Because there are lots of websites available selling sketchy products, make sure that you find one that you can trust.

We really like Peptide Sciences. The fact that they publish their test results demonstrating the purity of all their subjects really helps us feel comfortable that they are selling high-quality products.

In addition to that, Peptide Sciences:

  • Makes their product in the US.
  • Has convenient shipping. Orders within the US are received within 2 to 3 days. International orders can take up to 10 days.
  • Has secure, convenient payment methods. If you like credit cards, they’ll accept all the main ones. If you are into cyber currencies, Peptide Sciences also accepts Bitcoin, Ethereum, and some others.
  • Has great customer service. If you have any problems with your order or just want to ask a question, you can get in touch with them by phone or email.

Buy Tesamorelin from our #1 recommended vendor...

How to Order Tesamorelin in Your Country

The beauty of Peptide Science is that they deliver internationally. No matter where you’re located, if you are accessible by courier, you can order Tesamorelin online from Peptide Sciences.

There may be other vendors that are local to your country as well. Again, just be careful that you can trust the company and that you’re going to get an authentic product without fillers or additives.

Tesamorelin Review | Verdict

Tesamorelin is loved by users.

The Tesamorelin bodybuilding community is especially enthusiastic about it because it has such a powerful effect on burning fat, especially stubborn belly fat.

These results are not just user reported, but are also corroborated by several high-quality randomized controlled studies that find that “test subjects” lose significant amounts of fat. Some studies have found losses of up to 20% [6].

What’s great is that Tesamorelin is legal and available in pharmacies by prescriptions from your doctor.

It’s indicated for the lipodystrophy condition that can result from HIV treatments because of its powerful ability to burn fat.

But researchers and “test subjects” can also easily buy Tesamorelin online from Peptide Sciences.

Buy Tesamorelin from our #1 recommended vendor...


  1. Food and Drug Administration (2010). Chemistry Reviews: Application 22-505. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2010/022505Orig1s0
  2. Patel, A., Gandhi, H., & Upaganlawar, A. (2011). Tesamorelin: A hope for ART-induced lipodystrophy. Journal of Pharmacy And Bioallied Sciences, 3(2), 319.
  3. Reddit (2019). Tesamorelin Dosage/cycle. https://www.reddit.com/r/Peptides/comments/dt1axv/tesamorelin_dosagecycle/
  4. Dhillon, S. (2011). Tesamorelin. Drugs, 71(8), 1071-1091.
  5. Falutz, J., Allas, S., Blot, K., Potvin, D., Kotler, D., Somero, M., … & Turner, R. (2007). Metabolic effects of a growth hormone–releasing factor in patients with HIV. New England Journal of Medicine, 357(23), 2359-2370.
  6. Canadian Agency for Drugs and Technologies in Health (2016). Clinical review report: Tesamorelin (Egrifta). https://www.ncbi.nlm.nih.gov/books/NBK539124/
  7. Mangili, A., Falutz, J., Mamputu, J. C., Stepanians, M., & Hayward, B. (2015). Predictors of treatment response to tesamorelin, a growth hormone-releasing factor analog, in HIV-infected patients with excess abdominal fat. PloS one, 10(10).
  8. Tuffaha, S. H., Singh, P., Budihardjo, J. D., Means, K. R., Higgins, J. P., Shores, J. T., … & Brandacher, G. (2016). Therapeutic augmentation of the growth hormone axis to improve outcomes following peripheral nerve injury. Expert opinion on therapeutic targets, 20(10), 1259-1265.
  9. Friedman, S. D., Baker, L. D., Borson, S., Jensen, J. E., Barsness, S. M., Craft, S., … & Vitiello, M. V. (2013). Growth Hormone–Releasing Hormone Effects on Brain γ-Aminobutyric Acid Levels in Mild Cognitive Impairment and Healthy Aging. JAMA Neurology, 70(7), 883-890.
  10. Campbell, J. (2019). The Peptide Revolution in Modern Medicine w/Dr. William Seeds | TOT Revolution. https://www.youtube.com/watch?v=t60b8TXI8tE

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