Tesamorelin Dosage Calculator and Guide | What You MUST Know

tesamorelin dosage

Titus Thorne  |  Last Updated March 26, 2021  |  Tesamorelin

Tesamorelin is one of the most powerful peptides for fat loss on the market, but before you can benefit from its effects, you need to figure how best to tackle the actual Tesamorelin dosage.

Tesamorelin peptide is a little more complicated than other supplements because it is usually injected. The “test subject” has to reconstitute Tesamorelin from a powder, understand how to calculate the right dosage, and then actually do the injection.

Needless to say, that can all be slightly overwhelming.

We're here for you. In this article, we'll give you everything you need to understand Tesamorein dosing for your “test subjects”, from a Tesamorelin dosage calculator to providing guidance on the process of reconstituting Tesamorelin with water to the side effects you can expect, and more.

Buy Tesamorelin from the #1 online Peptides vendor in the world: Peptides Sciences

P.S: This is not medical or legal advice. This is strictly for entertainment purposes. We are not doctors - nor lawyers. All information below is presented for use on "test subjects" only. Not for human consumption. Please read my disclaimer.


 

What is Tesamorelin?

Tesamorelin peptide, also known by its trade name “Egrifta”, is a synthetic sequence of amino acids that have been created to mimic growth hormone-releasing hormone (GHRH) [1]. GHRH is one of the thousands of peptides in your body that play a role as a chemical signal to regulate bodily functions [2].

In addition to being a peptide for research purposes, Tesamorelin is also approved by the FDA as a prescription medication for lipodystrophy—the accumulation of fat around the midsection.

Tesamorelin peptide structure

Tesamorelin peptide has a chemical structure that is essentially the same as GHRH [3]. The primary function of GHRH is to signal to your body to release more growth hormone, which is also often called human growth hormone (HGH).

What is HGH?

HGH is a hormone that plays a critical role in helping your body to grow new tissue or repair old tissue. It helps build muscle, repair, and rejuvenate your skin, synthesize bone material, and much more[4]. It's especially important to bodybuilders and athletes who need to repair their muscles after a workout.

The problem is that HGH tends to decrease as we get older [5]. To combat this, some scientists have looked at the effects of HGH supplements. These have demonstrated positive benefits [6]… but they have also been associated with significant side effects [7].

Tesamorelin HGH

Fortunately, there's an alternative. HGH secretagogues—substances that stimulate your body to secrete its own HGH—are both effective and have fewer adverse effects. These allow you to experience increased HGH but without taking it directly.


tesamorelin


Tesamorelin Benefits and Uses

So what does Tesamorelin actually do? Well, there are many Tesamorelin benefits.

  • Increasing HGH. The biggest benefit of Tesamorelin is that it increases HGH [8, 9]. This is how it has all its other effects: by increasing the body's ability to grow and repair tissue.
  • Burning fat. Tesamorelin HGH has been found in a number of studies to significantly reduce fat—in the stomach, in muscles, and even in the liver [310, 11].
  • Increased muscle. Tesamorelin bodybuilding is popular in part because this substance has been found to help individuals build muscle strength, muscle density, and the size of muscles [12].
  • Improving cognition. Research is showing that Tesamorelin can actually help people perform better on cognitive tasks. This is true of people with mild cognitive impairments as well as those with normal cognition [13, 14, 15].
  • Nerve tissue repair. There is some evidence that suggests Tesamorelin could help repair damaged nerve tissue [16].
  • Reducing the risk of Cardiac disease. Preliminary research suggests that Tesamorelin could also be useful in reducing the risk of cardiovascular diseases [11, 17].

Is Tesamorelin legal?

It sounds wonderful… but is Tesamorelin legal?

The legal status of anything, of course, depends on where you are. Each country has its own rules.

But, yes, its legal to buy Tesamorelin in most countries.

The first way you can legally purchase Tesamorelin is by having a prescription for it. Prescriptions are provided by doctors for patients that suffer from lipodystrophy as a result of taking HIV medications.

The second way you can legally buy Tesamporelin online is if you are buying it for research purposes. Researchers can buy it legally as long as they plan to use it on “test subjects”.


Tesamorelin Side Effects

Tesamorelin is generally considered safe and well-tolerated by the vast majority of studies that have been done on it [3, 11, 18, 19, 20, 21, 22]. But there are some Tesamorelin side effects to be aware of [23]. Here they are along with their estimated incidence in users:

  • Injection site reactions, like pruritus, rash, pain, and swelling (3.1%)
  • Arthralgia (2.4%)
  • Pain in the extremities (1.1%)
  • Myalgia (1.1%)
  • Peripheral edema (1.1%)
  • Paresthesia (0.9%)
  • Hypoesthesia (0.7%)
  • Rash (0.7%)
  • Dysepsia (0.3%)
  • Muscle pain (0.3%)
  • Pruritus (0.3%)
  • Vomiting (0.3%)
  • Muscle stiffness (0.3%)
  • Carpal Tunnel Syndrome (0.2%)
  • Joint swelling (0.2%)
  • Night sweats (0.2%)
  • Palpitations (0.2%)

As you can see, the most common side effects only occur in about 3% of users… so these are not common. Still, be aware of them and see a doctor if they occur.


Tesamorelin Dosage Calculator and Guide

Okay, so if “test subjects” want to see some benefits, what kind of Tesamorelin dosage are we looking at?

Well, it depends in part on what effects you're looking for. Let's break down the Tesamorelin dose for each effect.

Tesamorelin for fat loss

When it's prescribed for lipodystrophy, the typical dose of Tesamorelin is:

  • 2 mg of Tesamorelin
  • in one injection each day
  • at night, at least 90 minutes after eating

Tesamorelin bodybuilding dosage

For bodybuilding, your “test subjects” can use less. A solid Tesamorelin bodybuilding dose is:

  • 1 mg of Tesamorelin
  • in one injection per day
  • at night, at least 90 minutes after eating
  • 5 days on, 2 days off

If you're really looking to see results, “test subjects” can stack it with 100 – 200 mcg of Ipamorelin.

Tesamorelin dose for cognition

For cognition, studies [14] have found success using the following dose of Tesamorelin:

  • 1 mg of Tesamorelin
  • in one injection per day
  • at night, 30 minutes before bed
  • 5 days on, 2 days off
  • for 20 weeks

Tesamorelin dose for anti-aging

Increased HGH in the body can help improve your skin and make you look younger. The following dose of Tesamorelin will help you achieve this:

  • 1 mg of Tesamorelin
  • in one injection per day
  • at night, at least 90 minutes after food
  • 5 days on, 2 days off

The best dose of Tesamorelin for injury recovery

Increased HGH in the body can also help you recover faster from injuries. Your “test subjects” can try this:

  • 1 mg of Tesamorelin
  • in one injection per day
  • at night, at least 90 minutes after food
  • 5 days on, 2 days off

How to take a dose of Tesamorelin

One of the biggest barriers to Tesamorelin and other peptides is that it needs to be injected subcutaneously—under the skin.

Usually, a nurse or doctor will teach patients how to take a Tesamorelin dose, but here's a quick:

  1. Wash your hands. Use soap and water. This will help prevent infection.
  2. Reconstitute the Tesamorelin dosage. This means you need to turn it from a solid powder into a liquid. Follow the instructions that come with it. Usually, you will reconstitute it by injecting bacteriostatic (sterile) water into the vial and then swirling (but not shaking) it until everything is dissolved.
  3. Ensure no particles. At this point, you also want to check to make sure there aren't any particles or discoloration. If there are, you don't want to inject it.
  4. Clean the injection area. You can do this with rubbing alcohol. Again, this helps prevent infection.
  5. Inject under the skin. Once you've successfully achieved your solution, you want to inject it into the skin. This is usually best done on your stomach, below the belly button. You don't want to inject in an area where there is already bruising, redness, or irritation. Also, avoid scar tissue.
  6. Rotate the location for each injection. That way you will avoid issues with over-injection in one area.

Following these instructions will help “test subjects” reap the benefits of Tesamorelin before and after while avoiding potential side effects and infection.

Other notes on Tesamorelin dosage

Here are some other notes about taking Tesamorelin that you should be aware of so your “test subjects” can get the most out of their experience.

  • Take Tesamorelin at night. The reason that it works best at night is that HGH is naturally at its highest when you're sleeping. This is when the body does most of its growth and repair work. Taking Tesamorelin before you go to bed will help boost its effects.
  • Take Tesamorelin at least 90 minutes after food. The reason for this is that food can interrupt how Tesamorelin is absorbed. It's better to take it with significant time between your last meal so that it works properly.
  • Get a good cycle. We usually don't want to be on peptides indefinitely—you have to give your body a break. A good cycle for Tesamorelin is 5 days on, 2 days off for a few months. Then take a month off. Of course, follow your doctor's advice on this.

Where to Buy Tesamorelin Online? | 2020 Guide

Our favorite online peptide vendor is Peptide Sciences.

They're the only vendor we recommend. The reason is that we've developed a trust for them over the years that we've used them. They've always provided us with high-quality products and any time there has been an issue with the order, they have responded immediately to fix it.

We love these things about Peptide Sciences:

  • Product Quality. We love that they publish laboratory analyses to prove that their product is high quality and that they post the results of those tests on their website. It really boosts our confidence in their product.
  • Payment options are convenient. We love being able to buy with cryptocurrency. But also, they can accommodate e-check and a number of the major credit cards. Super convenient and secure.
  • Quick shipping. Anyone living in the US should get their order within 2-3 days from Peptide Sciences. If you live in another country, they'll still ship to you, but it might take a little longer—up to 10 days. Still, that's pretty good.
  • Excellent customer service. We've never found such responsive customer service from our vendors as we've found with Peptide Sciences. They're so easy to get in touch with and they actually solve problems.

For those reasons, Peptide Sciences is our number 1 recommendation.


tesamorelin


Tesamorelin Dosage | Verdict

There's no comparison between the results of Tesamorelin before and after. It really works: it incinerates fat, builds muscle, and improves your cognitive faculties.

The trick is just getting the dose of Tesamorelin right for your “test subjects'” goals and also getting comfortable with injections.

If you can do those things, you'll be in a good position to benefit from the amazing effects of research peptides like Tesamorelin.

Buy Tesamorelin from our #1 recommended vendor...


References

  1. Food and Drug Administration (2010). Chemistry Reviews: Application 22-505. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2010/022505Orig1s0
    00ChemR.pdf
  2. Mine, Y., Li-Chan, E., & Jiang, B. (2010). Biologically active food proteins and peptides in health: an overview. Bioactive proteins and peptides as functional foods and nutraceuticals. Hoboken: Wiley‑Blackwell, 5-11.
  3. Dhillon, S. (2011). Tesamorelin. Drugs, 71(8), 1071-1091.
  4. Bergan-Roller, H. E., & Sheridan, M. A. (2018). The growth hormone signaling system: Insights into coordinating the anabolic and catabolic actions of growth hormone. General and Comparative Endocrinology258, 119-133.
  5. Bartke, A. (2019). Growth hormone and aging: Updated review. The World Journal of Men's Health37(1), 19-30.
  6. Jørgensen, J. O. L., Thuesen, L., Ingemann-Hansen, T., Pedersen, S. A., Jørgensen, I., Skakkebaek, N. E., & Christiansen, J. S. (1989). Beneficial effects of growth hormone treatment in GH-deficient adults. The Lancet333(8649), 1221-1225.
  7. Anderson, L. J., Tamayose, J. M., & Garcia, J. M. (2018). Use of growth hormone, IGF-I, and insulin for anabolic purpose: pharmacological basis, methods of detection, and adverse effects. Molecular and cellular endocrinology464, 65-74.
  8. Editorial, A. (2004). Pralmorelin: GHRP 2, GPA 748, Growth Hormone-Releasing Peptide 2, KP-102 D, KP-102 LN, KP-102D, KP-102LN. Drugs in R & D, 5, 236-239.
  9. Broglio, F., Boutignon, F., Benso, A., Gottero, C., Prodam, F., Arvat, E., … & Muccioli, G. (2002). EP1572: a novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man. Journal of Endocrinological Investigation, 25(8), RC26-RC28.
  10. Sivakumar, T., Mechanic, O. J., Fehmie, D. A., & Paul, B. T. (2011). Growth hormone axis treatments for HIV‐associated lipodystrophy: a systematic review of placebo‐controlled trials. HIV medicine, 12(8), 453-462.
  11. Stanley, T. L., Feldpausch, M. N., Oh, J., Branch, K. L., Lee, H., Torriani, M., & Grinspoon, S. K. (2014). Effect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: a randomized clinical trial. JAMA, 312(4), 380-389.
  12. Adrian, S., Scherzinger, A., Sanyal, A., Lake, J. E., Falutz, J., Dubé, M. P., … & Brown, T. T. (2019). The Growth Hormone Releasing Hormone analog, Tesamorelin, decreases muscle fat, and increases muscle area in adults with HIV. The Journal of Frailty & Aging, 8(3), 154-159.
  13. Zdravkovic, M., Søgaard, B., Ynddal, L., Christiansen, T., Agersø, H., Thomsen, M. S., … & Ilondo, M. M. (2000). The pharmacokinetics, pharmacodynamics, safety and tolerability of a single dose of NN703, a novel orally active growth hormone secretagogue in healthy male volunteers. Growth Hormone & IGF Research, 10(4), 193-198.
  14. Friedman, S. D., Baker, L. D., Borson, S., Jensen, J. E., Barsness, S. M., Craft, S., … & Vitiello, M. V. (2013). Growth Hormone–Releasing Hormone Effects on Brain γ-Aminobutyric Acid Levels in Mild Cognitive Impairment and Healthy Aging. JAMA Neurology, 70(7), 883-890.
  15. Baker, L. D., Barsness, S. M., Borson, S., Merriam, G. R., Friedman, S. D., Craft, S., & Vitiello, M. V. (2012). Effects of growth hormone-releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trial. Archives of Neurology, 69(11), 1420-1429.
  16. Tuffaha, S. H., Singh, P., Budihardjo, J. D., Means, K. R., Higgins, J. P., Shores, J. T., … & Brandacher, G. (2016). Therapeutic augmentation of the growth hormone axis to improve outcomes following peripheral nerve injury. Expert opinion on therapeutic targets, 20(10), 1259-1265.
  17. Falutz, J., Allas, S., Blot, K., Potvin, D., Kotler, D., Somero, M., … & Turner, R. (2007). Metabolic effects of a growth hormone–releasing factor in patients with HIV. New England Journal of Medicine, 357(23), 2359-2370.
  18. Zdravkovic, M., Christiansen, T., Eliot, L., Agersoe, H., Thomsen, M. S., Falch, J. F., … & Ilondo, M. M. (2001). The pharmacokinetics, pharmacodynamics, safety, and tolerability following 7 days daily oral treatment with NN703 in healthy male subjects. Growth Hormone & IGF Research, 11(1), 41-48.
  19. Svensson, J., Monson, J. P., Vetter, T., Hansen, T. K., Savine, R., Kann, P., … & Ilondo, M. M. (2003). Oral administration of the growth hormone secretagogue NN703 in adult patients with growth hormone deficiency. Clinical Endocrinology, 58(5), 572-580.
  20. Zdravkovic, M., Olsen, A. K., Christiansen, T., Schulz, R., Taub, M. E., Thomsen, M. S., … & Ilondo, M. M. (2003). A clinical study investigating the pharmacokinetic interaction between NN703 (tabimorelin), a potential inhibitor of CYP3A4 activity, and midazolam, a CYP3A4 substrate. European Journal of Clinical Pharmacology, 58(10), 683-688.
  21. Piccoli, F., Degen, L., MacLean, C., Peter, S., Baselgia, L., Larsen, F., … & Drewe, J. (2007). Pharmacokinetics and pharmacodynamic effects of an oral ghrelin agonist in healthy subjects. The Journal of Clinical Endocrinology & Metabolism, 92(5), 1814-1820.
  22. Luzi, L., Meneghini, E., Oggionni, S., Tambussi, G., Piceni-Sereni, L., & Lazzarin, A. (2005). GH treatment reduces trunkal adiposity in HIV-infected patients with lipodystrophy: a randomized placebo-controlled study. European Journal of Endocrinology, 153(6), 781-789.
  23. FDA (n.d.). Highlights of Prescribing Information: Egrifta. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/022505Orig1s010lbl.pdf

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