Titus Thorne

Last Updated August 11, 2021

Titus Thorne

 August 11, 2021

Sermorelin vs Ipamorelin.

Curious which of these research peptides is the right one to buy? Well, you’re in the right place.

Both sermorelin and ipamorelin work to increase the amount of human growth hormone (HGH) produced and secreted by the pituitary gland.

But while these two peptides can have similar effects, they work in slightly different ways.

In this post, we’ll give you a detailed rundown of both sermorelin and ipamorelin, including how they work, what benefits they offer and what side effects they may cause in test subjects. We’ll also share the best place to source them online.

Let’s get to it!

Buy Sermorelin from the #1 online Peptides vendor in the world: Peptides Sciences

Disclaimer: ResearchPeptides.org contains information about products that are intended for laboratory and research use only, unless otherwise explicitly stated. This information, including any referenced scientific or clinical research, is made available for educational purposes only. ResearchPeptides.org makes every effort to ensure that any information it shares complies with national and international standards for clinical trial information and is committed to the timely disclosure of the design and results of all interventional clinical studies for innovative treatments publicly available or that may be made available. However, research is not considered conclusive. ResearchPeptides.org makes no claims that any products referenced can cure, treat or prevent any conditions, including any conditions referenced on its website or in print materials.


What are Research Peptides?

Research peptides are short chains of amino acids that are linked by peptide bonds. They range from between two and fifty amino acids in length and fall under many different categories. Some peptides are isolated from natural sources and some are made artificially.

Longer chains of amino acids double over on themselves creating 3D shapes and are classified as proteins. By contrast, peptides are shorter chains that are typically two-dimensional. The US Food and Drug Administration (FDA) classifies chains of 40 amino acids or fewer as “peptides.”

Because of their small, flat structure, peptides are able to bind with a number of chemical receptors throughout the body that larger molecules and drugs cannot access.

The FDA has currently approved over 490 peptide products for a variety of uses. Some of these include treatments and prevention for:

  • Genetic disorders
  • Cancer
  • Infectious disease
  • Cardiovascular issues
  • Eye disorders
  • Immune system weakness
  • Bone disorders and osteoporosis
  • Respiratory disorders
  • Neurodegenerative disorders
  • Eye disorders

Both sermorelin and ipamorelin are peptides and we will explore the differences between them below.


What is Ipamorelin

Sermorelin acetate, commonly known as sermorelin, is a peptide analogue of human growth hormone-releasing hormone (GHRH). Whereas GHRH is a 44-amino acid peptide, sermorelin contains just the first 29 amino acids of GHRH yet has the same biological activity [1]. In other words, sermorelin is a fully functioning “fragment” of GHRH, making it the shortest peptide to have this ability.

Sermorelin was initially approved by the FDA in 1997 and sold under the trade name “Geref” [2]. It was indicated for the treatment of Growth Hormone Deficiency (GHD) in both children and adults and was also used as a diagnostic agent for assessing whether a patient’s pituitary gland was functioning properly.

Sermorelin’s FDA approval was withdrawn in 2008 for reasons other than safety and efficacy [3].

Mechanism of Action

Sermorelin works by mimicking the body’s endogenous human growth hormone-releasing hormone (GHRH). GHRH is a 44-amino acid brain-gut peptide that binds to the growth hormone-releasing hormone receptor (GHRH-R) and stimulates the pituitary gland to produce and release more HGH [4]. While sermorelin contains just the first 29 amino acids of the GHRH protein, its mechanism of action is identical.


Ipamorelin


Benefits of Ipamorelin

Ipamorelin benefits you by naturally increasing the amount of HGH in your body.

This has a number of potent benefits. For example, the additional GH from Ipamorelin means that:

  • You build more muscle mass in response to working out [4, 5]
  • You will find it easier to burn and lose fat [5]
  • Your body heals and repairs tissue more quickly [6]
  • You sleep and rest better [7].
  • Your skin and nails look younger [8]
  • Your bones grow more easily and become stronger [9]
  • Your sleep improves.

What is Sermorelin?

Sermorelin acetate, commonly known as sermorelin, is a peptide analogue of human growth hormone-releasing hormone (GHRH). Whereas GHRH is a 44-amino acid peptide, sermorelin contains just the first 29 amino acids of GHRH yet has the same biological activity [1]. In other words, sermorelin is a fully functioning “fragment” of GHRH, making it the shortest peptide to have this ability.

Sermorelin was initially approved by the FDA in 1997 and sold under the trade name “Geref” [2]. It was indicated for the treatment of Growth Hormone Deficiency (GHD) in both children and adults and was also used as a diagnostic agent for assessing whether a patient’s pituitary gland was functioning properly.

Sermorelin’s FDA approval was withdrawn in 2008 for reasons other than safety and efficacy [3].

Mechanism of Action

How exactly does ipamorelin work?

Ipamorelin is a growth hormone (GH) secretagogue that mimics ghrelin and selectively binds to the same GHSR-1a receptor as endogenous ghrelin [10]. This stimulates the pituitary gland to release GH, which in turn influences a range of anabolic processes such as energy usage, fat processing and appetite suppression [11].

What makes ipamorelin unique is that it’s the first GHRP-receptor agonist that stimulates GH release to an extent comparable with endogenous GHRH [9].

Ipamorelin’s secondary action is to reduce somatostatin — a hormone that inhibits the production and release of HGH. By lowering somatostatin levels, ipamorelin stimulates the pituitary gland to produce more GH [9].


Sermorelin Acetate

 


Benefits of Sermorelin

As ipamorelin lacks FDA approval, it currently offers no approved medical uses. There’s a notable lack of data regarding ipamorelin’s clinical effects in humans. However, various studies have observed the following benefits:

Stimulate body weight gain and GH release in animals

A 1998 paper by K Raun et al. found that ipamorelin could stimulate the release of GH from primary rat pituitary cells and swine [9], and concluded that the peptide could be a “very interesting candidate for future clinical development.”

A 2002 study published in the European Journal of Anatomy found that ipamorelin treatment could stimulate body weight gain and GH release in young female rats [12].

Potential benefits for patients undergoing open laparotom

In 2014, ipamorelin was briefly investigated in phase II clinical trials for the treatment of postoperative ileus [13]. These trials were discontinued because the “clinical endpoints did not reach statistical significance when comparing ipamorelin to placebo” [5]. However, data from this study indicated that ipamorelin treatment may shorten the recovery times of patients undergoing open laparotomy [14].

Potential treatment for hypogonadal males

Ipamorelin was included in the aforementioned review by Deepankar et al. of growth hormone secretagogues (GHS) in the modern management of body composition in hypogonadal males. This review noted that ipamorelin was one of a number of GHS that can “significantly improve body composition while ameliorating specific hypogonadal symptoms including fat gain and muscular atrophy” [5]. Ipamorelin’s proposed clinical use in hypogonadal males and men with SH is “total weight gain” [5].

Buy Sermorelin from our #1 recommended vendor...


Differences between Ipamorelin and Sermorelin?

Both Ipamorelin and Sermorelin work to increase the amount of GH in your system. This is important because, as you get older, the GH you have starts to decline rapidly.

They also both do this by stimulating your body to release more GH naturally. That means you don’t have to worry about losing your natural GH production, as you might if you took GH directly.

So what are the differences between them?

One of the big differences is their chemical structure. Ipamorelin and Sermorelin have different chemical properties, which means that they act on different receptors. They both activate receptors that tell your pituitary gland to release more GH, but they do that using different receptors.

Ipamorelin also has a secondary function, which is to reduce somatostatin, another hormone that inhibits GH. Sermorelin does not have this secondary function.

There are also some differences in the effects that each has on your body, including the side effects. However, the side effects of both Ipamorelin and Sermorelin are typically rare and mild. Both are generally considered safe.


Ipamorelin


Recommended Dosing/Cycle

In this section, we’ll explain how to choose the best dose and cycle for Ipamorelin vs Sermorelin.

Ipamorelin

The most common form of Ipamorelin dosage is via injection under the skin or into the muscle.

Beginners usually will want to start with the following dosing cycle:

  • 1 microgram (mcg) per kilogram (kg) of body weight, up to 100mcg or 150mcg
  • in a single dose of Ipamorelin per day
  • for a cycle of 8 to 12 weeks
  • with 1 month off

You will find that your body’s natural GH production increases, which will come with a number of benefits.

You want to keep the amount per dose the same throughout the cycle; don’t increase it during the cycle. After you’ve finished a cycle, you can consider increasing your Ipamorelin dosage.

As you go, you can experiment with larger doses. For example, you might increase the dosage to

  • 200mcg to 300mcg per day
  • split into two to three injections per day
  • on a cycle of 8 to 12 weeks
  • with 1 month off before the next cycle

Ensure to rotate injection sites.

Sermorelin

Sermorelin is also most commonly taken via injection.

Sermorelin dosage recommendations are usually anywhere between 100 mcg and 500 mcg per day. 400 mcg and 500 mcg are very high doses and will be more likely to result in uncomfortable side effects than lower doses.

We recommend that you start with:

  • 1 mcg per kilogram of body weight, up to between 100 mcg to 200 mcg, per day
  • injected once daily
  • on a cycle of 4 to 6 weeks
  • with 1 month off before the next cycle

To reconstitute Sermorelin, inject the diluent into the vial of sermorelin against the wall of the glass vial. Then swirl the vial until the powder has been completely dissolved. If there are any particles that have not been dissolved or if the mixture is cloudy, do not administer or inject.

Tips for both Ipamorelin and Sermorelin

There are a few things to keep in mind for both of these peptides.

  • The best time to take both Ipamorelin and Sermorelin is during the late evening before bedtime. That’s because it will allow you to have your peak GH while you’re asleep when your body is regenerating itself. This will help you get the best results.
  • Some suggest that these work best if you’re a bit hungry. If you have eaten in the two hours before you take it, it may not be as effective. Also try to avoid simple carbohydrates and sugars since these spike your insulin levels, which again can interfere with the action of sermorelin and increasing GH.
  • For both of these peptides, make sure that you’re well-hydrated by drinking plenty of water. That’s because your body uses more water than usual with these injections and while it’s repairing itself. It’s much better to be over-hydrated than under-hydrated, so make sure to drink lots and lots of water.
  • Try to eat well. Make your caloric intake stable and avoid binge eating. This will help keep your blood sugar and body chemistry stable for your hormones to work properly.

How to Order Research Peptides Online?

Ordering research peptides online is easy. The hard part is finding a reputable company and source. You want to make sure that any company you order from has the following:

  • High-quality products: Lots of people out there are selling snake oil. Be careful. Insist on looking for companies that can prove the quality of their products.
  • Customer reviews: A good company will usually leave a footprint on the internet. Look for companies where independent reviews have given them a high rating.
  • Customer service: If you have questions, you should be able to call or email. Make sure that you can get in touch with the company if you have any problems or questions.
  • Fair price: Ipamorelin costs should not be super high, or super low. Look for companies that sell it at a reasonable price. That goes for sermorelin costs as well.
  • Refund policy: What will happen if they send the wrong product? Make sure they’ll pay you back or send a new order.

This can be a bit of a sketchy industry, so make sure you know you’re getting good quality products.

We’ve looked around and tried a few different companies. By far our favorite is Peptide Science. We like them because:

  • They provide certificates of analysis of all their products, showing that they are at least 99% pure. They’re designed for researchers, so they have done all the tests and you can see them right on the website.
  • They are a US-based company that ships all over the world. If you’re in the US you should get your order within a couple of days; 7 to 10 for other countries.
  • Payment is secure and convenient. They’ll take all major credit cards and they’ll even accept cryptocurrencies like Bitcoin and Ethereum.
  • They have great customer service. You can call or email them and you’ll talk to a real person.
  • Refund policy. They’ll make sure they make it right if you don’t get what you order or if there’s another problem.

Side Effects and Safety Concerns?

Both Ipamorelin and Sermorelin are considered very safe to use. However, you should still understand what the possible side effects of using each of these could be.

Ipamorelin

Some reported Ipamorelin side effects include:

  • Water retention in wrists or ankles
  • Headache
  • Pain, rash, or soreness at injection sites [11]
  • Lightheadedness
  • Transient fever
  • Insulin resistance [12]
  • Neoplasm
  • Hypertension [12]

Because it can change blood sugar and blood pressure, people with diabetes or cardiovascular conditions should avoid using Ipamorelin.

Sermorelin

Some reported Ipamorelin side effects include:

  • Pain, swelling, or redness at the injection site
  • Difficulty swallowing
  • Itching
  • Dizziness
  • Flushing
  • Tiredness
  • Headache
  • Vomiting
  • Hives
  • Issues sitting still

Of patients taking Sermorelin in clinical trials, less than 1% experienced these side effects.

Both Sermorelin and Ipamorelin are largely side-effect free for most people when the dose is prescribed by a medical practitioner. However, allergic reactions can occur with both (as with any substance). If you experience an allergic reaction, you should seek medical attention.

In general, you should start with a low dose and gradually increase over time to see how it affects your body. Try not to change dose levels in the middle of a cycle.


Sermorelin Acetate


Sermorelin Vs. Ipamorelin | Verdict

Sermorelin and Ipamorelin are similar in that they both stimulate your body to produce more growth hormone.

But they do that by binding to different chemical receptors. That means they can have slightly different effects and side effects.

Which is better? Well, neither.

It depends on what you’re looking for and how each affects your particular body.

To make the best decision about which peptide is the best fit for your goals, experiment. Try both and see what works best for you and your body.

Buy Sermorelin from our #1 recommended vendor...


References

1. Jiménez-Reina, L., Cañete, R., De la Torre, M. J., & Bernal, G. (2020). Chronic in vivo Ipamorelin treatment stimulates body weight gain and growth hormone (GH) release in vitro in young female rats. European Journal of Anatomy, 6(1), 37-45.

2. Prakash, A., & Goa, K. L. (1999). Sermorelin. BioDrugs, 12(2), 139-157.

3. THPdb: A database of FDA approved therapeutic peptides and proteins. Retrieved March 27, 2020. webs.iiitd.edu.in

4. Taaffe, D. R., Pruitt, L., Reim, J., Hintz, R. L., Butterfield, G., Hoffman, A. R., & Marcus, R. (1994). Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men. The Journal of Clinical Endocrinology & Metabolism, 79(5), 1361-1366.

5. Thompson, J. L., Butterfield, G. E., Gylfadottir, U. K., Yesavage, J., Marcus, R., Hintz, R. L., … & Hoffman, A. R. (1998). Effects of human growth hormone, insulin-like growth factor I, and diet and exercise on body composition of obese postmenopausal women. The Journal of Clinical Endocrinology & Metabolism, 83(5), 1477-1484.

6. Erotokritou-Mulligan, I., Holt, R. I., & Sönksen, P. H. (2011). Growth hormone doping: A review. Open access journal of sports medicine, 2, 99.

7. Ghigo, E., Arvat, E., Giordano, R., Broglio, F., Gianotti, L., Maccario, M., … & Deghenghi, R. (2001). Biologic activities of growth hormone secretagogues in humans. Endocrine, 14(1), 87-93.

8. Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.

9. Andersen, N. B., Malmlöf, K., Johansen, P. B., Andreassen, T. T., Ørtoft, G., & Oxlund, H. (2001). The growth hormone secretagogue Ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats. Growth Hormone & IGF Research, 11(5), 266-272.

10. Bagno, L. L., Kanashiro‐Takeuchi, R. M., Suncion, V. Y., Golpanian, S., Karantalis, V., Wolf, A., … & Valdes, D. (2015). Growth hormone–releasing hormone agonists reduce myocardial infarct scar in swine with subacute ischemic cardiomyopathy. Journal of the American Heart Association, 4(4), e001464.

11. Souza, F. M., & Collett-Solberg, P. F. (2011). Adverse effects of growth hormone replacement therapy in children. Arquivos Brasileiros De Endocrinologia & Metabologia, 55(8), 559-565.

12. Honeyman, T. W., Goodman, M. H., & Fray, J. C. (1983). The effects of growth hormone on blood pressure and renin secretion in hypophysectomized rats. Endocrinology, 112(5), 1613-1617.

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