Sermorelin Side Effects | The #1 A-Z Guide

sermorelin side effects

Titus Thorne

Last Updated May 4, 2021

Curious about potential Sermorelin side effects​?

Then you're in the perfect place.

Inside this detailed guide, we'll breakdown exactly what you need to know about Sermorelin risks and rewards.

The peptide community has been buzzing about their positive results and experiences using the Sermorelin peptide.

These benefits often include reduced body fat, increased lean muscle mass, higher energy levels, and improvements in skin quality.

However, since peptide therapy, in general, is fairly new, there are lots of questions about the potential side effects of using Sermorelin.

This article will cover what Sermorelin is, Sermorelin benefits, where to buy it and, most importantly, the possible Sermorelin side effects.

Buy Sermorelin from the #1 online Peptides vendor in the world: Peptides Sciences

P.S: This is not medical or legal advice. This is strictly for entertainment purposes. We are not doctors - nor lawyers. All information below is presented for use on "test subjects" only. Not for human consumption. Please read my disclaimer.

What is Sermorelin?

Sermorelin is a synthetic peptide composed of a chain of amino acids. It belongs to a class of growth hormone-releasing hormones (GHRHs) [1]. Essentially, GHRHs are a group of hormones working collectively to regulate your pituitary gland’s release of growth hormone (GH) to make sure that your body functions optimally.

This means that it was made to imitate our body’s organically created peptides in order to boost the production of human growth hormone (HGH).

HGH is crucial in managing the body’s composition, cardiovascular fitness, tissue repair and regeneration, bone growth and protein synthesis [2].

As you get older, your body’s production of HGH decreases, typically around 30 years of age [2]. The decline can be as much as 10% per decade. This decline in HGH production makes it more difficult for your body to build muscle and is one of the reasons why it takes longer to recover from physical activity as we get older.

What Sermorelin does is get the HGH levels in your blood naturally to go back up to the levels they were at when you were younger by stimulating your pituitary gland to produce and release more of HGH [2].

By utilizing Sermorelin, your body is encouraged to increase production of its own natural GH.

This is much better for your body than simply taking HGH directly. Taking HGH directly is both illegal if it’s not by prescription, but it can also lead to uncomfortable side effects.

Sermorelin is able to raise GH levels but minimize potential negative side-effects since your body isn’t being flooded with additional GH all at once.

Instead, Sermorelin stimulates the release of your natural GH at a steady and consistent rate.

And it seems to have some useful effects: Users describe improvements in sleep, faster recovery from injuries, increased muscle mass, decreased fat, and younger-looking skin [3].


Benefits of Sermorelin

Numerous Sermorelin benefits have been reported by both research and users. Below we go over some of the more well-discussed physical and mental benefits. Keep in mind that these benefits of Sermorelin – are not really from Sermorelin, per se.

Instead they mostly come from the additional amounts of GH being released into the body. Here is a list of some of the effects on “test subjects” that Sermorelin has by raising HGH levels [14, 5]:

  • Increases lean body mass and builds muscle faster: Users, specifically those who are Sermorelin bodybuilding, report that Sermorelin helps them to build muscle and muscle mass at a faster rate [3]. It also seems to improve muscle strength [6]. A related benefit that is also reported is the accelerated breakdown of body fat (aka lipolysis) which is stimulated by the increase in GH [3].
  • Repairs tissue: Research has found that Sermorelin usage can aid in the body’s post-workout restoration and recovery from injuries [27].
  • Increases collagen: GH can stimulate proteins within the body, including collagen. More collagen means smoother, thicker, younger-looking skin [3, 89].
  • Better sleep quality: Sermorelin can assist the body in making adjustments to some of the chemicals that are associated with sleep [10]. . A number of “test subjects” report that Sermorelin enhances their quality of sleep and makes it more restful.
  • Greater bone density: Research on older individuals shows evidence that Sermorelin can boost bone density [3], which has potential to mitigate the effects of osteoporosis.
  • Faster recovery: Some research with animals has shown that Sermorelin can assist in repairing heart damage post-heart attack [1112].

Taken together, all of the above results reported by “test subjects” in research and user reports point towards Sermorelin having similar positive outcomes on the body to other GH releasing peptides and substances.

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Sermorelin Side Effects | What You MUST Know

Overall, Sermorelin usage is considered to be safe [1314].

It’s approved by the FDA and is regularly prescribed to individuals with growth hormone deficiency. Of course, As with any supplement, please consult with your physician or medical professional before adding it to your regiment.

The majority of users rarely report Sermorelin side effects, and when they do, the reported side effects are usually very minor. It is also important to note that higher dosages increase the chances of experiencing side effects.

The most commonly reported mild side effects by users are [13]:

  • Swelling, redness, pain, or irritation at the site of administration
  • Flushed face
  • Headache
  • Nausea
  • Lividity
  • Funny taste in the mouth
  • Vomiting

Less commonly, people report some side effects that could be slightly more severe. Get in touch with your doctor or another medical professional if you are having any of the following Sermorelin side effects [13]:

  • Rash
  • Hives
  • Itching
  • Difficulty breathing
  • Tightness in chest
  • Swelling in the mouth, tongue, lips, or other facial features.

As previously stated, the risks of experiencing side effects go up with Sermorelin dosage. It is recommended that you always start with a lower dose to see how your body responds, and increase over time depending on the response and your goals.

To maximize the effects of Sermorelin, it is recommended that users take Sermorelin on an empty stomach around bedtime, since nighttime is when the body has its highest natural GH levels.

Additionally, as with other peptides or supplements, it is not recommended that you change your dosage mid-cycle. This can cause some confusion in your system and trigger your body to respond negatively.

It is always better to be consistent and finish out one full dosing cycle before changing your dosage, so your body has time to adjust. It also helps with keeping your Sermorelin and GH levels consistent.

Sermorelin and Cancer?

There has been some discussion about the link between peptide use and increased risk of cancer. First, let’s be clear that there is currently no research that links Sermorelin use to any types of cancer.

Some use of other hormones is associated with an increased risk of some cancers; for example, there is some evidence that other forms of hormone treatment (e.g., estrogen and testosterone) are linked to cancer [15]. In addition, using HGH as part of a direct treatment can lead to a ‘jump’ in your hormone levels, creating an imbalance that makes you more at risk for cancer. So taking HGH directly is not the best idea.

On a more positive note, since Sermorelin is a peptide and HGH that stimulates your body’s natural GH production, it provides a more consistent release and does not cause that big ‘jump’ in hormone levels. So it shouldn’t put a person at risk the way that synthetic HGH might.

Again, Sermorelin peptide is not associated with the same risks for cancer as other hormones have. There is absolutely no research that links Sermorelin with cancer.

Where to Buy Sermorelin Online? | 2021 Guide

Unlike some other peptides, you are able to obtain a prescription for Sermorelin since it is utilized as a method for determining someone’s natural growth hormone secretion. Keep in mind that, in the United States, Sermorelin is only prescribed for this reason, so you would not be able to obtain it for other use that way.

However, Sermorelin can be found fairly easily and legally purchased online for research purposes if you are examining how it affects “test subjects”.

That being said, it is important to do your research on where to buy Sermorelin online. Many companies offering peptides for purchase online are questionable in terms of quality and reputation.

After extensive research of our own, Peptide Sciences is by far our go-to favorite. They offer high-quality products at reasonable prices and are an overall very reputable company. Peptide Sciences has:

  • High-quality products: They offer pure Sermorelin HGH, and provide a certificate of lab analysis that is easily accessible on their website.
  • Fast and convenient shipping: If you are in the US, shipping takes about 2 to 3 days. If you are ordering internationally, it is about 7 to 10 days.
  • Excellent customer service: If you have any questions or issues with your order, it is very easy to get a hold of an actual person. They’re great and helpful.
  • Easy payment options: Peptide Sciences use a secure payment system and accept all major credit cards, as well as some forms of cryptocurrency.

They’re great…we highly recommend them.


Side Effects of Sermorelin? | Verdict

What's the verdict on Sermorelin usage and side effects?

Overall, Sermorelin is considered quite safe for the majority of users.

Researcher and “test subjects” report few, if any, side effects compared to using steroid and other GHs.

This is not to say that there are no potential side effects or risks with using Sermorelin.

In addition, anyone under the age of 18 years old is not recommended to take Sermorelin unless they are prescribed it by a doctor for a growth hormone deficiency.

As with any supplement, it is important to do your research for sourcing and only buy high-quality Sermorelin from a reputable source. Taking higher quality products will also minimize the risks of negative side effects. In addition, use a small dosage when first starting out, increasing as needed for subsequent cycles depending on results and goals.

Finally, remember to always consult with your doctor or health care professional before adding any supplements or peptides to your regime.

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  1. Prakash, A., & Goa, K. L. (1999). Sermorelin. BioDrugs, 12(2), 139-157.
  2. Erotokritou-Mulligan, I., Holt, R. I., & Sönksen, P. H. (2011). Growth hormone doping: A review. Open access journal of sports medicine, 2, 99.
  3. Rudman, D., Feller, A. G., Nagraj, H. S., Gergans, G. A., Lalitha, P. Y., Goldberg, A. F., & Mattson, D. E. (1990). Effects of human growth hormone in men over 60 years old. New England Journal of Medicine, 323(1), 1-6.
  4. Laron, Z. (1995). Growth hormone secretagogues. Drugs, 50(4), 595-601.
  5. Khorram, O., Yeung, M., Vu, L., & Yen, S. S. C. (1997). Effects of [norleucine27] growth hormone-releasing hormone (GHRH)(1–29)-NH2 administration on the immune system of aging men and women. The Journal of Clinical Endocrinology & Metabolism, 82(11), 3590-3596.
  6. Vittone, J., Blackman, M. R., Busby-Whitehead, J., Tsiao, C., Stewart, K. J., Tobin, J., … & Roth, J. (1997). Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1–29) in healthy elderly men. Metabolism, 46(1), 89-96.
  7. Baumann, G. P. (2012). Growth hormone doping in sports: a critical review of use and detection strategies. Endocrine reviews, 33(2), 155-186.
  8. Proksch, E., Schunck, M., Zague, V., Segger, D., Degwert, J., & Oesser, S. (2014). Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Skin pharmacology and physiology, 27(3), 113-119.
  9. Doessing, S., Heinemeier, K. M., Holm, L., Mackey, A. L., Schjerling, P., Rennie, M., … & Flyvbjerg, A. (2010). Growth hormone stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis. The Journal of Physiology, 588(2), 341-351.
  10. Shepherd, B. S., Johnson, J. K., Silverstein, J. T., Parhar, I. S., Vijayan, M. M., McGuire, A., & Weber, G. M. (2007). Endocrine and orexigenic actions of growth hormone secretagogues in rainbow trout (Oncorhynchus mykiss). Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 146(3), 390-399.
  11. Bagno, L. L., Kanashiro‐Takeuchi, R. M., Suncion, V. Y., Golpanian, S., Karantalis, V., Wolf, A., … & Valdes, D. (2015). Growth hormone–releasing hormone agonists reduce myocardial infarct scar in swine with subacute ischemic cardiomyopathy. Journal of the American Heart Association, 4(4), e001464.
  12. Kanashiro-Takeuchi, R. M., Szalontay, L., Schally, A. V., Takeuchi, L. M., Popovics, P., Jaszberenyi, M., … & Hare, J. M. (2015). New therapeutic approach to heart failure due to myocardial infarction based on targeting growth hormone-releasing hormone receptor. Oncotarget, 6(12), 9728.
  13. (2015). Sermorelin acetate.
  14. Mayo Clinic (n.d.). Sermorelin (Injection Route).
  15. Lacey, J.V., Mink, P.J., Lubin, J.H., Sherman, M.E., Troisi, Hartge, P., Schatzkin, A., & Schairer, C. (2002). Menopausal Hormone Replacement Therapy and Risk of Ovarian Cancer. JAMA, 17, 334-341.

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