Sermorelin | Review of Benefits, Dosage, Side Effects, and More

sermorelin review

Titus Thorne

Last Updated May 4, 2021

​Curious about ​Sermorelin?​ ​Wondering if this research peptide offers vast benefits? Well, you’ve come to the right spot.

Inside this Sermorelin review, we’ll discuss everything you must know.

Sermorelin has recently become popular within the health and wellness community, mainly due to its ability to naturally restore your body’s growth hormone levels. Having higher amounts of growth hormone in the blood allows the body to recover from injuries and workouts faster, increase lean muscle mass, burn fat, and rejuvenate aging skin.

You might have seen some crazy claims on Reddit or elsewhere about everything it can do. Lots of people are talking about it as a wonder peptide that is taking the fitness world by storm.

But does it actually work? What are the effects of Sermorelin before and after? And what are Sermorelin’s side effects?

We’re going to cover all of that in this article, so buckle up.

Buy Sermorelin from the #1 online Peptides vendor in the world: Peptides Sciences

P.S: This is not medical or legal advice. This is strictly for entertainment purposes. We are not doctors - nor lawyers. All information below is presented for use on "test subjects" only. Not for human consumption. Please read my disclaimer.

What is Sermorelin?

​First, let’s get clear about what Sermorelin actually is.

Sermorelin acetate is basically just a peptide, which means it’s a chain of amino acids that is not quite as long as a protein [1]. Sermorelin is made up of 29 amino acids.

Sermorelin acetate is a synthetic analog of your body’s own, natural growth hormone-releasing hormone (GHRH) [2]. It is sold under the brand names Geref and Gerel. Because it mimics your body’s own GHRH, it has the same effect, which is to increase the amount of growth hormone (GH; also known as human growth hormone or HGH) in your body.

How it works is a little complicated. HGH is regulated in humans in a complex interaction between the nervous system and the endocrine system. The pituitary gland is especially important since this is where your body manufactures growth hormone and where it is released [2].

Sermorelin’s chemical structure is very similar to GHRH, so it is able to bind to the same receptors that GHRH can. When it binds to those receptors, it tells the pituitary gland to release more HGH. Thus, the ultimate effect of Sermorelin is higher concentrations of HGH in the body.

Why does that matter?

Well, HGH plays a super important role in your body’s tissue building and repair functions. Virtually all of the tissue in your body ismade through a process that is facilitated by HGH. If your body has higher HGH levels, it is able to create and repair tissue, like muscle, skin, tendons, and bones, easier and quicker [2].

HGH is plentiful in your body when you’re young and growing. But it starts to decrease as you get older. That is one of the reasons that older people tend to recover from injuries slower than younger people do, and also why they have more difficulty putting on muscle.

Ultimately, the effect of Sermorelin is to help your body construct tissue, but it does that indirectly by increasing the amount of HGH coursing through your system.


Does Sermorelin Actually Work?

It does.

There is really good evidence that Sermorelin peptide is an effective growth hormone secretagogue; in other words, it really does increase HGH levels in your body [1, 4].

Sermorelin also has been found to be an effective treatment for children with growth hormone deficiency. These are children with clinically low amounts of growth hormone, which hinders their growth. Sermorelin has been found to be effective at increasing the amount of HGH in their bodies so that their growth returns to normal [3].

Another use of Sermorelin is to assess and diagnose issues with HGH in adults [3].

Is Sermorelin Legal?

Sermorelin is absolutely legal to buy and use in the United States. If you live outside of the United States, you should check its legal status with your local authorities.

Sermorelin acetate, under the trade names Geref has been approved since 1997 [5]. It is indicated for the treatment of growth hormone deficiencies in both children and adults. It is also indicated as a diagnostic agent that can help assess whether the pituitary gland is functioning properly and releasing HGH.

The FDA has currently not approved the use of Sermorelin for any other uses, including as a supplement. However, many Sermorelin bodybuilding users have shared their experiences, and research subjects have also been exposed to Sermorelin for uses outside of treating growth hormone deficiency syndrome.

In most jurisdictions, you need a prescription to obtain Sermorelin from the drug store. However, researchers are able to order it for their “test subjects” online without a prescription.

Sermorelin Before and After

So what do users of Sermorelin peptide find? They notice a ton of differences using Sermorelin before and after.

For example, we’ve seen the following reviews around the Internet. These are some of the experiences that people actually using Sermorelin have had (although, of course, everyone’s experiences are different).

Users notice the following effects:

  • feeling younger, full of energy, and having more vitality
  • Improved scores on measures of bone density
  • Improved strength and flexibility
  • Faster metabolism and more fat burning
  • Wrinkles and fine lines disappearing from skin
  • Faster lean muscle building
  • Quicker recovery from workouts and injuries.

Sermorelin Benefits and Uses

Sermorelin HGH effects are large, and users are all over it. But what does the research say? Is there scientific evidence that it is effective?

We cover the scientific literature here so you can get a good sense of what the latest research says about Sermorelin benefits.


Sermorelin is often called an anti-aging peptide. The reason for this is that it helps increase your body’s HGH back to the levels that you had in your body when you were in your 20s. That means you can heal and build tissue as if you were young again.

But it can also have the effect of making people look younger, too. It helps fight signs of aging. This is because the HGH that Sermorelin releases plays a vital role in building collagen, which is what helps your skin keep its elasticity and smoothness [6, 7].

In one study, elderly participants with elevated levels of HGH showed significantly thicker skin than those in a control group who didn’t have higher levels of HGH [8]. The results from these “test subjects” are consistent with other users of Sermorelin: they find that they end up with smoother, younger-looking skin.

For those reasons, Sermorelin could be an important tool to fight aging [9].

Muscle Building

Users are right about the muscle-building effect, too. Research has found that Sermorelin is very effective at increasing the amount of HGH in the blood [1]. Further research has found that higher levels of HGH in the blood are associated with increased muscle mass.

In one study, elderly individuals that had heightened HGH levels had an 8.8% increase in lean muscle mass. And that wasn’t even with exercising or diet changes [8].

Increasing levels of lean muscle mass is one of the most famous outcomes of HGH, and these are enhanced by Sermorelin.

Fat Burning

HGH doesn’t just build muscle mass, it also decreases fat. In one study, participants that were made to have higher HGH levels had a reduction of adipose tissue (body fat) by 14% compared to a control group [8]. And again, those changes were not due to the effects of diet or exercise.

It should be noted that the best effects of Sermorelin HGH will come from regular exercise and a healthy diet. You shouldn’t expect a miracle change to your body. But, if you exercise consistently and eat well, the research suggests that “test subjects” have the best outcomes when they take Sermorelin.

Repairs Tissue

Another benefit is that Sermorelin contributes to the repair of tissue [2]. This has the benefit of helping “test subjects” recover faster from workouts. It also helps them heal from injuries quicker as well.

Sleep Quality

Sermorelin plays a role in regulating Orexin, which is a hormone that is involved in the body’s circadian rhythm and sleep cycles [10]. In doing that, Sermorelin likely contributes to the regulation and promotion of high-quality sleep in “test subjects”.

Bone Density

Studies have found that Sermorelin helps increase bone growth. In one study of older individuals, researchers found that Sermorelin can boost bone mineral density [8]. This is consistent with many user reports of people that suffer from osteoporosis and for whom Sermorelin is effective at increasing bone density.

Heart Health

Studies have shown that Sermorelin plays an important role in repairing cardiac tissue as much as it does in other tissues. One study in animals found that Sermorelin helped reduce scarring following a heart attack [11].

In addition, it was found to reduce the number of cardiac cells that died, increase the chemical components that are needed to repair heart tissue, increase the number and size of arteries and veins going to the heart so that it is better nourished, and reduce inflammation [11, 12].

Sermorelin Side Effects

In general, Sermorelin is considered safe for the vast majority of people to use [13, 14].

Some research peptides don’t have that much research on their use in humans because they are not approved for consumption. But since Sermorelin is an approved drug, there’s quite a bit of information on its side effects. In general, few users of Sermorelin experience side effects.

Importantly, Sermorelin results in way fewer side effects than if you took HGH directly. That’s because if you take synthetic HGH, you create a spike in your blood HGH levels, and this messes with your body chemistry. It can also shut down your body’s natural HGH-producing capabilities. That means you stop being able to make as much HGH yourself. That’s not what you want.

Sermorelin doesn’t have those effects. Since it works by stimulating your own body to produce HGH, it doesn’t stop your natural HGH production—it actually increases it. And, because it stimulates HGH naturally, there’s never a spike of HGH levels. Instead, they get raised slowly and steadily. So the side effects are lower than taking HGH directly.

However, users and “test subjects” have reported that there are some Sermorelin side effects.

Some of the mild side effects that Sermorelin users find include [13, 14]:

  • Swelling, redness, pain, or irritation at the site of administration
  • Flushed face
  • Headache
  • Nausea
  • Aggression
  • Funny taste in the mouth
  • Vomiting

Some users, much more rarely, report more severe side effects that can include [3,5]:

  • a rash, itchiness, or hives
  • difficulty breathing
  • tightness in chest
  • swelling in the mouth

In general, side effects are more common with high doses. Start with a lower dosage so that you can see what effect it has on your body. As always, consult your doctor before beginning a supplement regimen.

Sermorelin Dosage Guide

What Sermorelin dosage should you begin with? We’re glad you asked.

First of all, if you’re using Sermorelin prescribed by a doctor, your doctor will tell what the Sermorelin dose should be and teach you how to administer it. Always make sure that you follow the amount prescribed by your medical practitioner.

“Test subjects” in research are given a variety of different doses, but the general research doses range between 100 and 500 micrograms (mcg) per day. The cycle for a beginner generally looks like this:

  • 100 mcg to 300 mcg per injection
  • 1 injection per day
  • for 6 to 12 weeks
  • with 1 month off

Sermorelin acetate comes in a powder form. You then have to reconstitute it with bacteriostatic water by injecting the diluent into the vial of Sermorelin and swirling the vial (very gently) until the contents are entirely dissolved. Do not shake. If you can see any particles or the solution is cloudy, do not use it. Wipe off the vial with an antiseptic solution first to prevent infection.

Once it is reconstituted, you can inject it under the skin or into a muscle. Your doctor or medical provider will show you how to do this. Use sterile, small, disposable syringes such as insulin syringes.

You can store Sermorelin, once it is reconstituted, in the fridge. It should be stored between 2 and 8 degrees celsius (between 36 and 46 degrees Fahrenheit). Do not freeze it. Also, try to keep it away from light and moisture [13].

Keep in mind that 10 “units” on a syringe is equivalent to 200 mcg. So if you want to take 100 mcg, take 5 “units”.

“Test subjects” should take Sermorelin dosage at night before bed. And take it at least 2 hours after eating. That ensures that their HGH is highest while their body is sleeping and repairing itself.

Where to Buy Sermorelin Online? | 2021 Guide

You can buy Sermorelin from pharmacies if you have a prescription. If you don’t have a prescription, you can buy Sermorelin for research online. Just be careful to find a good, reputable company.

We always recommend Peptide Sciences because they are an American company with a really good reputation and good user reviews. Here’s why they are the most reliable on the web:

  • High-quality products: The thing about peptides is that you never really know what you’re getting. Peptide Sciences provides peace of mind by publishing the results of chemical tests online so you can see exactly what the quality of your product is.
  • Fast shipping: Shipping within the US takes about 2 to 3 days. They also ship internationally and you can expect your international package within 10 days.
  • Convenient payment options: They accept all major credit cards as well as several types of cyber currencies. And all payment options are secured with encryption.
  • Great customer service: If you have any problems or questions, you can get in touch with an actual person by calling or emailing. They may be the only people in the business that still picks up the phone and we love it.

Buy Sermorelin from our #1 recommended vendor...

How to Order Sermorelin in Your Country

Honestly, Peptide Science ships everywhere that is accessible by courier.

Rather than searching around for a company that might be sketchy, just go with one that has a good reputation and that has international shipping.

You don’t want to mess around with what goes in your body, so go for quality and wait the 7 to 10 days it will take to arrive.

Sermorelin vs. Ipamorelin

What is better…

Sermorelin or Ipamorelin?

Honestly, it depends on your body. Both Sermorelin and Ipamorelin work in a similar way: by stimulating a user’s body to produce more HGH.

Then how are they different? It basically is just chemistry. Ipamorelin is shorter. It looks, chemically, like the human body’s own growth hormone-releasing peptides (GHRPs). Sermorelin is longer and mimics your body’s growth hormone-releasing hormones (GHRHs). So they have a chemical difference.

But they both stimulate more HGH.

To find out which one is better for you, try both and see. They may feel different for your body, or you may notice one has effects that you like better. Be a “test subject”, do an experiment, and see which works better.


Sermorelin Review | Verdict

​This Sermorelin review should hopefully show that it is excellent for increasing the natural HGH that your body produces. If you have growth hormone deficiency, your doctor can prescribe this for you to get your HGH levels back up to what they should be.

If you don’t have a prescription, you might wonder, is Sermorelin legal? It is if you’re using them for research. You can order them for research purposes from Peptide Sciences and they’ll get to you quickly. Users and “test subjects” report that Sermorelin can help build muscle mass, lose fat, and rejuvenate the skin.

It might be exactly what you’re looking for.

Buy Sermorelin from our #1 recommended vendor...


  1. Prakash, A., & Goa, K. L. (1999). Sermorelin. BioDrugs, 12(2), 139-157.
  2. Baumann, G. P. (2012). Growth hormone doping in sports: a critical review of use and detection strategies. Endocrine reviews, 33(2), 155-186.
  3. Xu, Z. (2016). Growth Hormone-Releasing Hormone. In Handbook of Hormones (pp. 144-e18B). Academic Press.
  4. Laron, Z. (1995). Growth hormone secretagogues. Drugs, 50(4), 595-601.
  5. US Food and Drug Administration, (n.d.). Drugs at FDA: FDA-Approved drugs.
  6. Proksch, E., Schunck, M., Zague, V., Segger, D., Degwert, J., & Oesser, S. (2014). Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Skin pharmacology and physiology, 27(3), 113-119.
  7. Doessing, S., Heinemeier, K. M., Holm, L., Mackey, A. L., Schjerling, P., Rennie, M., … & Flyvbjerg, A. (2010). Growth hormone stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis. The Journal of physiology, 588(2), 341-351.
  8. Rudman, D., Feller, A. G., Nagraj, H. S., Gergans, G. A., Lalitha, P. Y., Goldberg, A. F., … & Mattson, D. E. (1990). Effects of human growth hormone in men over 60 years old. New England Journal of Medicine, 323(1), 1-6.
  9. Walker, R. F. (2006). Sermorelin: A better approach to management of adult-onset growth hormone insufficiency?. Clinical interventions in aging, 1(4), 307.
  10. Shepherd, B. S., Johnson, J. K., Silverstein, J. T., Parhar, I. S., Vijayan, M. M., McGuire, A., & Weber, G. M. (2007). Endocrine and orexigenic actions of growth hormone secretagogues in rainbow trout (Oncorhynchus mykiss). Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 146(3), 390-399.
  11. Bagno, L. L., Kanashiro‐Takeuchi, R. M., Suncion, V. Y., Golpanian, S., Karantalis, V., Wolf, A., … & Valdes, D. (2015). Growth hormone–releasing hormone agonists reduce myocardial infarct scar in swine with subacute ischemic cardiomyopathy. Journal of the American Heart Association, 4(4), e001464.
  12. Kanashiro-Takeuchi, R. M., Szalontay, L., Schally, A. V., Takeuchi, L. M., Popovics, P., Jaszberenyi, M., … & Hare, J. M. (2015). New therapeutic approach to heart failure due to myocardial infarction based on targeting growth hormone-releasing hormone receptor. Oncotarget, 6(12), 9728.
  13. (2015). Sermorelin acetate.
  14. Mayo Clinic (n.d.). Sermorelin (Injection Route).

Table Of Contents