Titus Thorne

Last Updated August 15, 2021

Titus Thorne

 August 15, 2021

Curious about ipamorelin benefits? You’re in the right spot.

Over recent years, ipamorelin has been much discussed as a purported weight loss agent and performance enhancement aid for athletes and bodybuilders.

More recently, ipamorelin has been touted by anti-aging clinics as a treatment that can delay or even reverse the visible signs of aging, improve sleep quality, boost metabolism, and aid with inflammatory issues. The best part? Ipamorelin, if properly dosed, seems to have negligible side effects.

But does ipamorelin really offer any of these benefits?

In this A-Z guide, we’ll provide you with an overview of the potential benefits of ipamorelin so that you can determine whether it could be a useful candidate for further research.

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Disclaimer: ResearchPeptides.org contains information about products that are intended for laboratory and research use only, unless otherwise explicitly stated. This information, including any referenced scientific or clinical research, is made available for educational purposes only. ResearchPeptides.org makes every effort to ensure that any information it shares complies with national and international standards for clinical trial information and is committed to the timely disclosure of the design and results of all interventional clinical studies for innovative treatments publicly available or that may be made available. However, research is not considered conclusive. ResearchPeptides.org makes no claims that any products referenced can cure, treat or prevent any conditions, including any conditions referenced on its website or in print materials.


What is Ipamorelin?

Ipamorelin is a growth hormone (GH) secretagogue that was developed by the Danish pharmaceutical company Novo Nordisk [1]. More specifically, ipamorelin is a pentapeptide—a chain of five amino acids—that acts as a growth hormone (GH) releasing peptide. It has been shown to display high GH releasing potency and efficacy in animal and human trials [2].

How does it work?

In animals and humans, growth hormone (GH) is created and dispersed by cells in the pituitary gland, which helps regulate the body’s natural hormone levels for the endocrine system [3]. Ipamorelin is a type of peptide that stimulates the production and secretion of endogenous GH.

Ipamorelin works by mimicking ghrelin, a hormone that is naturally produced by the enteroendocrine cells of the gastrointestinal tract [4]. For this reason, ipamorelin is commonly referred to as a “ghrelin mimetic.” It selectively binds the same GHSR-1a receptors as endogenous ghrelin and stimulates the pituitary cells to release more GH.

This, in turn, influences a range of anabolic processes in the body including [5]:

  • Energy usage
  • Fat processing
  • Appetite suppression

Ipamorelin is unique in the sense that it’s the first growth hormone-releasing peptide (GHRP) receptor agonist that stimulates GH release to an extent comparable with endogenous growth hormone-releasing hormone (GHRH) [1].

Simultaneously, ipamorelin regulates the release of somatostatin, a growth hormone inhibiting hormone (GHIH) that hinders the body’s natural GH output. This suppression of somatostatin levels by ipamorelin encourages the body to naturally increase its GH levels [1].


Ipamorelin


Benefits of Ipamorelin

So what are the benefits of ipamorelin?

Ipamorelin currently lacks FDA approval and remains a research peptide that has no approved medical uses. Data regarding ipamorelin’s clinical effects in humans is lacking. However, various studies have observed that ipamorelin offers the following benefits:

Ipamorelin and Disease Management

Some research suggests that ipamorelin may be useful in helping to manage certain diseases through its ability to mimic ghrelin and stimulate the release of growth hormone (GH).

For example, ipamorelin has been shown to counteract the glucocorticoid-induced decrease in bone formation of adult rats and these findings suggest that it may be beneficial in humans [6].

Ipamorelin’s ability to improve gastric motility and accelerate gastric emptying has been evaluated by several studies [7, 8]. A 2012 study by Greenwood-Van Meerveld et al. found that ipamorelin accelerates gastric emptying in fasted adult male rats with induced postoperative ileus (POI). These findings indicate that it could be a promising treatment for a common condition known as delayed gastric emptying.

In 2014, Beck et al. conducted a small, multicenter, double-blinded, placebo-controlled trial that aimed to evaluate whether ipamorelin could benefit POI in bowel resection patients. This trial was discontinued because the “clinical endpoints did not reach statistical significance when comparing ipamorelin to placebo” [9].

However, data from this study indicated that ipamorelin treatment may shorten the recovery times of patients undergoing open laparotomy [10]. This indicates that ipamorelin may potentially offer benefits for patients receiving this type of surgery.

Ipamorelin and GH-release

Several animal studies have evaluated ipamorelin’s ability to increase GH-release. K Raun et al. concluded that ipamorelin can stimulate the release of GH from pituitary cells in rats and swine “with a potency and efficacy similar to GHRP-6” [1].

Research published in the European Journal of Anatomy in 2002 found that ipamorelin treatment could stimulate GH release in young female rats. Tests showed that in vivo ipamorelin treatment prompts rats’ pituitary cells to produce and distribute more GH [11].

Ipamorelin and Body Composition

Ipamorelin has also been shown to increase the body weight of animals [11, 12]. Lall et al. found that female GH-deficient mice injected twice daily with 250 µg/kg ipamorelin for 9 weeks increased by 15.3% while non-GH-deficient mice increased by 16.9%. Mice in both groups that were injected with human GH increased in size by 95.5% and 27.5% respectively. However, while GH led to increased liver weight, ipamorelin did not increase the weight of the rodent’s dissected organs [12].

As noted by Deepankar et al., ipamorelin may help manage issues related to body composition in hypogonadal males. Its proposed clinical use in hypogonadal males and men with SH is “total weight gain” [9].

Deepankar et al. identified ipamorelin as one of a number of growth hormone secretagogues (GHS) that can “significantly improve body composition while ameliorating specific hypogonadal symptoms including fat gain and muscular atrophy” [9].

Purported anabolic and fat loss benefits

Anecdotal evidence indicates that ipamorelin is highly sought after among bodybuilders and athletes for its purported ability to increase strength and muscle mass, while simultaneously decreasing levels of body fat. However, a review of the available research shows that there is no convincing supporting evidence.

For instance, when Lall et al. conducted a 9-week study into ipamorelin’s effects on GH-deficient and non-GH-deficient mice, researchers found that ipamorelin actually increased total body fat percentages in GH-intact mice [12].

Nevertheless, proponents of ipamorelin for bodybuilding and fat loss point to its ability to increase HGH levels, and research that has linked GH supplementation to increased muscle mass and athletic performance.

For example, a randomized trial conducted in 2010 and funded primarily by the World Anti-Doping Agency (WADA) found that recreationally trained athletes who received 2 mg/day of GH for 8 weeks reduced their fat mass and increased their lean body mass [13].

While this trial did not involve ipamorelin, its findings suggest that growth hormone secretagogues (GHS) like ipamorelin may indirectly offer comparable benefits by stimulating the production and release of endogenous HGH. This is believed to be the main reason why ipamorelin is popular as a GH doping agent [14].

HGH plays a vital role in the muscle creation process and the theory is that by increasing levels of HGH in the body, ipamorelin can help to increase lean muscle mass [15]. As metabolism increases in tandem with muscle mass, this can stimulate the fat-burning process.

Furthermore, because ipamorelin increases GH, it may also support faster post-workout muscle recovery. This is important in bodybuilding because muscles become damaged during workouts, and muscle fibers reform after workouts (aka hypertrophy) [16].

Note: under no circumstances do we encourage the self-administration of unregulated research peptides like ipamorelin for recreational purposes.

Ipamorelin and Anti-Aging

More recently, ipamorelin has been touted by anti-aging clinics as an effective way to slow and diminish the visible signs of aging [15]. While there is research showing that GH treatment can result in the reduction of fine lines and wrinkles by promoting collagen growth and repair of skin tissue, a review by Bartke A et al into growth hormone and aging concluded that “elevation of GH levels into the supranormal (pathological) range is associated with increased disease risks and reduced life expectancy likely representing an acceleration of aging” [17].

There is no available data from human clinical trials to support ipamorelin treatment for the purpose of anti-aging.

Ipamorelin and Bone Health

Ipamorelin seems to also improve bone growth and formation [18].

Research conducted on adult rats provides evidence that ipamorelin, at appropriate dosage dosage, may be a factor in increasing bone mineral density content and bone growth, both of which contribute to more durable, healthier bones.

Ipamorelin and GHD Treatment

As we’ve discussed, ipamorelin stimulates the body’s natural GH production. From childhood to adolescence, GH is mostly responsible for our body’s composition, bone density, and growth.
However, some children experience growth hormone deficiency (GHD), which occurs when they are unable to maintain the GH levels that are necessary to maintain natural body composition. This can occur both in our development stages and later in life since our GH levels decrease with age.

Studies indicate that GHRHs similar to ipamorelin can be useful in activating GH secretion in the pituitary in order to increase GH growth to help with reducing the detrimental effects of GHD [18].

Ipamorelin Dosage Calculator

The results and effectiveness of ipamorelin treatment appear to be dose-dependent. But what is the optimal dose for this peptide?

The only available human clinical trial data comes from Beck et al. [8]. This small proof of concept study involved just 114 patients, which is too small to draw any statistical conclusions. However, it shows that patients received “intravenous infusions of 0.03-mg/kg ipamorelin twice daily, on postoperative day 1 to 7 or hospital discharge.”

In clinical settings, ipamorelin is most commonly administered via subcutaneous injection, as this is the most efficient way for the body to process the peptide.

Anecdotal evidence suggests that when ipamorelin is used by recreational and professional athletes and bodybuilders, it is commonly taken in conjunction with other GHRH analogues like sermorelin, as in sermorelin-ipamorelin blend. As these two peptides work along different pathways, taking a blend is believed to increase GH secretion more effectively.

Ipamorelin is also commonly administered in conjunction with CJC-1295, a peptide that stimulates HGH production and can lead to improved immune functioning and reduce signs of aging [19]. As CJC-1295 and ipamorelin stimulate GH secretion via different receptors in the body, this combination can have a cumulative effect whereby it intensifies the release of GH and boosts the GH concentration levels.


Where to Buy Ipamorelin Online? | 2021 Guide

There are quite a few options for medical researchers interested in purchasing ipamorelin online. As when ordering any supplement or drug online, it is important to do due diligence to ensure that you are buying high-quality products. Since ipamorelin remains a research peptide, its sale is unregulated in many countries and there are some questionable suppliers.

So make sure you choose a supplier that you can trust.

Our top choice is Research Peptides. They have a stellar reputation for providing high-quality, research-grade peptides. Other benefits of using their services include:

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Ipamorelin


Ipamorelin Benefits | Verdict

So what are the benefits of ipamorelin?

Having reviewed the available research, it is clear that ipamorelin offers a number of proven and purported benefits. Ipamorelin has the ability to increase GH levels in the body and its interactions with the GI tract appear to be an important factor in determining overall body composition and levels of body fat.

The above literature cited in this guide draws attention to ipamorelin as a potent and selective GH stimulator that significantly influences body composition, adiposity, and the GI system. Adverse effects appear to be rare, and this peptide definitely warrants further human studies to evaluate its effects. It is certainly an interesting candidate for future research.


References

  1. Raun, K, Hansen, B., Johansen, N., Thogersen, H, Madsen, K, Ankersen, M, & Andersen, P. (1998). Ipamorelin, the first selective growth hormone secretagogue. European Journal of Endocrinology. 139 (5): 552–561.
  2. Gobburu, J.V. S., Agersø, H., Jusko, William J., & Ynddal, Lars (1999). Pharmacokinetic-Pharmacodynamic Modeling of Ipamorelin, a Growth Hormone Releasing Peptide, in Human Volunteers. Pharmaceutical Research. 16 (9): 1412–1416.
  3. Florini, J. R. (1987). Hormonal control of muscle growth. Muscle & Nerve: Official Journal of the American Association of Electrodiagnostic Medicine, 10(7), 577-598.
  4. Kojima M, Kangawa K. Ghrelin: structure and function. Physiol Rev. 2005 Apr;85(2):495-522. doi: 10.1152/physrev.00012.2004. PMID: 15788704.
  5. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab. 2001 Dec;86(12):5992. doi: 10.1210/jcem.86.12.8111. PMID: 11739476.
  6. Anderson, N.B., Malmlof, K., Johansen, P.B., Andreassen., T.T., Ortoft, G., & Oxlund, H. (2001). The Growth Hormone Secreatgoge Ipamorelin Counteracts Glucocrticoid-Induced Decrease in Bone Formation of Adult Rats. Growth Hormone & IGF Research. 11(5): 266-272.
  7. Greenwood-Van Meerveld B, Tyler K, Mohammadi E, Pietra C. Efficacy of ipamorelin, a ghrelin mimetic, on gastric dysmotility in a rodent model of postoperative ileus. J Exp Pharmacol. 2012 Oct 19;4:149-55. doi: 10.2147/JEP.S35396. PMID: 27186127; PMCID: PMC4863553.
  8. Beck DE, Sweeney WB, McCarter MD; Ipamorelin 201 Study Group. Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients. Int J Colorectal Dis. 2014 Dec;29(12):1527-34. doi: 10.1007/s00384-014-2030-8. Epub 2014 Oct 21. PMID: 25331030.
  9. Sinha, Deepankar K et al. “Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males.” Translational andrology and urology vol. 9,Suppl 2 (2020): S149-S159. doi:10.21037/tau.2019.11.30
  10. Delaney CP, Marcello PW, Sonoda T, Wise P, Bauer J, Techner L. Gastrointestinal recovery after laparoscopic colectomy: results of a prospective, observational, multicenter study. Surg Endosc. 2010 Mar;24(3):653-61. doi: 10.1007/s00464-009-0652-7. Epub 2009 Aug 18. PMID: 19688390.
  11. Estrada, R. Cañete; Jiménez-Reina, L.; de la Torre, M.J.; Bernal, J. (2002). “Chronic In Vivo Ipamorelin Treatment Stimulates Body Weight Gain and Growth Hormone (GH) Release In Vitro in Young Female Rats. European Journal of Anatomy. 6(1): 37–46.
  12. Lall S, Tung LY, Ohlsson C, Jansson JO, Dickson SL. Growth hormone (GH)-independent stimulation of adiposity by GH secretagogues. Biochem Biophys Res Commun. 2001 Jan 12;280(1):132-8. doi: 10.1006/bbrc.2000.4065. PMID: 11162489.
  13. Meinhardt U, Nelson AE, Hansen JL, Birzniece V, Clifford D, Leung KC, Graham K, Ho KK. The effects of growth hormone on body composition and physical performance in recreational athletes: a randomized trial. Ann Intern Med. 2010 May 4;152(9):568-77. doi: 10.7326/0003-4819-152-9-201005040-00007. PMID: 20439575.
  14. Erotokritou-Mulligan, I., Holt, R. I., & Sönksen, P. H. (2011). Growth hormone doping: A review. Open access journal of sports medicine, 2, 99.
  15. Welle, S., Thornton, C. H. A. R. L. E. S., Statt, M. A. R. C. I. A., & McHenry, B. (1996). Growth hormone increases muscle mass and strength but does not rejuvenate myofibrillar protein synthesis in healthy subjects over 60 years old. The Journal of Clinical Endocrinology & Metabolism, 81(9), 3239-3243.
  16. Cureton, K. J., Collins, M. A., Hill, D. W., & McElhannon, J. F. (1988). Muscle hypertrophy in men and women. Medicine and Science in Sports and Exercise, 20(4), 338-344.
  17. Bartke A. Growth Hormone and Aging: Updated Review. World J Mens Health. 2019 Jan;37(1):19-30. doi: 10.5534/wjmh.180018. Epub 2018 May 11. PMID: 29756419; PMCID: PMC6305861.
  18. Verónica Mericq, Fernando Cassorla, Teresa Salazar, Alejandra Avila, Germán Iñiguez, Cyril Y. Bowers, George R. Merriam, Effects of Eight Months Treatment with Graded Doses of a Growth Hormone (GH)-Releasing Peptide in GH-Deficient Children, The Journal of Clinical Endocrinology & Metabolism, Volume 83, Issue 7, 1 July 1998, Pages 2355–2360, https://doi.org/10.1210/jcem.83.7.4969
  19. Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006 Mar;91(3):799-805. doi: 10.1210/jc.2005-1536. Epub 2005 Dec 13. PMID: 16352683.

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