Titus Thorne

Last Updated May 4, 2021

Wondering about Ipamorelin benefits? You’re in the right spot.

There has been much discussion about the benefits of Ipamorelin, specifically as an effective weight loss and performance aid for athletes and bodybuilders [1].

More recently, Ipamorelin peptide therapy has been touted as a marvel against signs of visible aging, as well as improving the quality of your sleep, boosting your metabolism, and aiding with inflammatory issues. The best part? It seems to have negligible side effects.

But does Ipamorelin really have all those beneficial effects?

Here, we will provide you with a comprehensive overview of what the potential benefits of Ipamorelin are in order for you to determine if it could be a useful addition to your health supplement regime.

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P.S: This is not medical or legal advice. This is strictly for entertainment purposes. We are not doctors - nor lawyers. All information below is presented for use on "test subjects" only. Not for human consumption. Please read my disclaimer.

What is Ipamorelin?

Ipamorelin is a synthetically created peptide composed of five amino acids [2]. More broadly, peptides are compounds composed of amino acids (aka the “building blocks” of proteins). Peptides help trigger the body’s biological functions.

Ipamorelin is a category of peptide that stimulates the production of natural growth hormone (GH), which is also known as human growth hormone (HGH) [3].

HGH is created and dispersed by the pituitary gland. The pituitary gland regulates the body’s natural hormone levels for the endocrine system. However, it is sometimes not able to organically produce enough HGH. And HGH production naturally decreases with age.

How does it work?

This is where Ipamorelin HGH comes in. Ipamorelin is a robust GH stimulator, meaning that it assists your body’s natural GH production. Ipamorelin works by simulating the function of particular hormones and molecules, which then prompt the body to produce and distribute more natural human growth hormone (HGH) [4]. Since it is chemically similar to growth hormone-releasing peptide 1 (GHRP-1), it activates the same receptors as GHRP-1, thereby having the ability to mimic its effects (e.g., building muscle).

Simultaneously, Ipamorelin regulates the release of somatostatin, a growth hormone inhibiting hormone (GHIH) that hinders the body’s natural GH output. This suppression of somatostatin levels by Ipamorelin encourages the body to naturally increase its GH levels.


Benefits of Ipamorelin

So what are the benefits of Ipamorelin? There’s quite a bit of research evidence out there looking at Ipamorelin benefits. But people’s experiences with Ipamorelin before and after also can be different.

Here we provide a clearer and specific breakdown of each of the main potential uses and benefits of Ipamorelin and the research on these uses.

Ipamorelin Dosing and Muscle Growth

Amongst bodybuilders and athletes, Ipamorelin is one of the top choices for fat burning peptides, in conjunction with a routine workout program. Numerous studies have shown that Ipamorelin bodybuilding can be highly beneficial.

Ipamorelin is great for bodybuilders because it stimulates HGH levels. HGH is a vital part of the muscle creation process. By increasing the organic HGH levels in your body, Ipamorelin helps to increase lean muscle mass and body composition after a workout [6]. As a result of this enhancement in muscle mass, your metabolism is increased which, in turn, helps you lose weight more quickly by also aiding in fat burning.

Further, because Ipamorelin assists in increasing GH, it can also be beneficial in faster post-workout muscle recovery. This is important in bodybuilding because muscles become damaged during workouts, with muscle fibers reforming after the workouts (aka hypertrophy) [7].

Ipamorelin causes an increase in growth hormone, which in turn speeds up the repair and the creation of muscles. Because Ipamorelin boosts muscle recovery and repair, Ipamorelin bodybuilding results in quicker muscle and injury recovery [8].

Ipamorelin and Anti-Aging

More recently, Ipamorelin has considered as an effective way to slow and diminish the visible signs of aging [9].

Research shows that Ipamorelin stimulates the creation of IGF-1, a hormone that promotes bone and body tissue regrowth. This effect of Ipamorelin can result in the reduction of fine lines and wrinkles by promoting collagen growth and repair of skin tissue [10].

All of this can result in a smoother, more youthful overall look, making Ipamorelin an attractive anti-aging aid option.

Ipamorelin and Bone Health

Ipamorelin seems to also improve bone growth and formation.

Research with rats provides evidence that Ipamorelin, given the right dosage, may be a factor in increasing bone mineral density content and bone growth, both of which contribute to more durable, healthier bones [11, 12].

This potential for stimulating bone growth and mineral bone density may also be a useful method in helping with childhood bone growth, as well as mitigating the negative impacts of osteoporosis with aging [5, 13].

Ipamorelin and Disease Management

Some research suggests that Ipamorelin may also be useful in helping to manage certain diseases through its stimulation of GH.

Like other GH peptide therapies, Ipamorelin therapy has the ability to increase immune system functioning, mitigating the effects of disease. For example, it is frequently used in HIV patients to boost their immune systems [14].

Ipamorelin has also been shown to help with some of the symptoms associated with inflammatory bowel/constipation conditions and post-intestinal surgeries. Some studies show that Ipamorelin dosage can reduce constipation and speed up gut healing [15]. There is also evidence that it is related to a reduction in recovery time and stimulation of bowel movements in postoperative ileus (a common condition following abdominal surgery), leading to better patient outcomes [16].

Ipamorelin and GHD Treatment

As we’ve discussed, Ipamorelin stimulates the body’s natural GH production. From childhood to adolescence, GH is mostly responsible for our body’s composition, bone density, and growth.

However, some children experience growth hormone deficiency (GHD), which occurs when they are unable to maintain the GH levels that are necessary to maintain natural body composition. This can occur both in our development stages and later in life since our GH levels decrease with age.

Studies indicate that GHRHs similar to Ipamorelin can be useful in activating GH secretion in the pituitary in order to increase GH growth to help with reducing the detrimental effects of GHD [17].

Ipamorelin Dosage Calculator

The results and effectiveness of Ipamorelin also depend on the Ipamorelin dosing. Ipamorelin is most frequently administered in liquid form as an injection, as this is the most efficient way for your body to process it for quicker results.

Most growth hormone secretagogue types are dosed using 1 microgram (mcg) per kilogram (kg) of body weight [18].

But there is some evidence suggesting that the effectiveness of Ipamorelin increases with intake levels. The majority of Ipamorelin users take about 200mcg to 300mcg per dosage [19], injecting two to three times per day for an 8- to 12-week cycle.

That being said, Ipamorelin dosage and calculations vary based on the user’s goals. Keep in mind that the higher the dosage, the bigger the rise in the generation of the growth hormone, and also, the greater the chance of experiencing side effects.

In general, a medical professional/physician should be consulted before adding any new drug to your health regiment.

Where to Buy Ipamorelin Online? | 2021 Guide

There are quite a few options for purchasing Ipamorelin online. As when ordering any supplement or drug online, it is important to be careful and do your research to ensure that you are getting the best quality products. Since Ipamorelin is not yet officially regulated in many countries, there is an online grey market with some questionable suppliers.

So make sure you choose a supplier that you can trust.

Our top choice is Research Peptides. They have a stellar reputation and record for providing high quality, research-grade peptides. Other benefits of using their services include:

  • Quick shipping: Packages arrive within the US within 2-3 business days.
  • Convenient payment: They accept credit cards, but also cryptocurrency.
  • Customer service: They’re helpful and it’s easy to get in touch with a real person if you have a problem.

When using peptide therapy, it is common to combine or “stack” two or more peptides to maximize the beneficial results.

Another peptide, CJC 1295, also seems to encourage GH production that can lead to improved immune functioning and reduce aging signs [20]. CJC 1295 is also similar to Ipamorelin in that it can stimulate GH production without activating other hormones.

Some evidence suggests that CJC 1295 Ipamorelin benefits are better when the two compounds are used together [21]. Research shows that using a CJC 1295 + Ipamorelin blend dosage can stimulate GH using different receptors in the body. This combination can have an additive effect whereby it intensifies the release of GH and boosts the GH concentration levels.

Thus, using this combination of CJC 1295 and Ipamorelin may be particularly useful in fighting the signs and symptoms of aging, as well as boosting all of the other benefits of Ipamorelin.

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Ipamorelin Benefits | Verdict

So what are the benefits of Ipamorelin?

There are many. Using Ipamorelin will result in increasing the amount of growth hormone in your body. This will help your body recover faster from workouts and increase muscle growth. It can also help your body repair skin tissue and help your skin look younger.

For additional benefits, you can expect Ipamorelin to contribute to healthy bones and it may even help treat some diseases. These effects may be increased with a CJC 1295 + Ipamorelin blend dosage.

If you’re looking for a boost of growth hormone without the bad side effects of taking HGH directly, Ipamorelin may be a good option for you.

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  1. Raun, K, Hansen, B., Johansen, N., Thogersen, H, Madsen, K, Ankersen, M, & Andersen, P. (1998). Ipamorelin, the first selective growth hormone secretagogue. European Journal of Endocrinology. 139 (5): 552–561.
  2. Gobburu, J.V. S., Agersø, H., Jusko, William J., & Ynddal, Lars (1999). Pharmacokinetic-Pharmacodynamic Modeling of Ipamorelin, a Growth Hormone Releasing Peptide, in Human Volunteers. Pharmaceutical Research. 16 (9): 1412–1416.
  3. Florini, J. R. (1987). Hormonal control of muscle growth. Muscle & Nerve: Official Journal of the American Association of Electrodiagnostic Medicine, 10(7), 577-598.
  4. Estrada, R. Cañete; Jiménez-Reina, L.; de la Torre, M.J.; Bernal, J. (2002). “Chronic In Vivo Ipamorelin Treatment Stimulates Body Weight Gain and Growth Hormone (GH) Release In Vitro in Young Female Rats. European Journal of Anatomy. 6(1): 37–46.
  5. Johansen, P.B., Nowak, J., Skjaerbaek, C., FLyvbjerg, A., Andreassen, T.T., Wilken, M., & Orskov, H. (1999). Ipamorelin, a New Growth-Hormone-Releasing Peptide, Induces Longitudinal Bone Growth in Rats. Growth Hormone & IGF Research. 9(2): 106-113.
  6. Anderson, N.B., Malmlof, K., Johansen, P.B., Andreassen., T.T., Ortoft, G., & Oxlund, H. (2001). The Growth Hormone Secreatgoge Ipamorelin Counteracts Glucocrticoid-Induced Decrease in Bone Formation of Adult Rats. Growth Hormone & IGF Research. 11(5): 266-272.
  7. Cureton, K. J., Collins, M. A., Hill, D. W., & McElhannon, J. F. (1988). Muscle hypertrophy in men and women. Medicine and Science in Sports and Exercise, 20(4), 338-344.
  8. Erotokritou-Mulligan, I., Holt, R. I., & Sönksen, P. H. (2011). Growth hormone doping: A review. Open access journal of sports medicine, 2, 99.
  9. Welle, S., Thornton, C. H. A. R. L. E. S., Statt, M. A. R. C. I. A., & McHenry, B. (1996). Growth hormone increases muscle mass and strength but does not rejuvenate myofibrillar protein synthesis in healthy subjects over 60 years old. The Journal of Clinical Endocrinology & Metabolism, 81(9), 3239-3243.

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