Titus Thorne

Last Updated August 15, 2021

Titus Thorne

 August 15, 2021

Heard about CJC-1295 and want to calculate the appropriate dosage for your research? If so, this CJC-1295 dosage calculator and guide will tell you what you need to know.

Calculating the correct CJC-1295 dosage is far from straightforward. This powerful peptide is a research chemical and hasn’t yet been evaluated by the FDA. This begs the question: Is CJC-1295 safe — and if so, what dosage should you take?

With this guide we aim to address these all-important questions and help you calculate the right CJC-1295 dosage to administer to your subjects.

Buy CJC-1295 from the #1 online Peptides vendor in the world: Peptides Sciences

Disclaimer: ResearchPeptides.org contains information about products that are intended for laboratory and research use only, unless otherwise explicitly stated. This information, including any referenced scientific or clinical research, is made available for educational purposes only. ResearchPeptides.org makes every effort to ensure that any information it shares complies with national and international standards for clinical trial information and is committed to the timely disclosure of the design and results of all interventional clinical studies for innovative treatments publicly available or that may be made available. However, research is not considered conclusive. ResearchPeptides.org makes no claims that any products referenced can cure, treat or prevent any conditions, including any conditions referenced on its website or in print materials.


What Is CJC-1295?

CJC-1295 is a peptide that stimulates your pituitary gland to release most Human Growth Hormone (HGH). It’s essentially a modified version (or “analogue”) of growth hormone-releasing hormone (GHRH) that helps increase the amount of GH in your body. Its most well-known iteration, CJC-1295 DAC, was developed by the Canadian biotech company ConjuChem Technologies in the mid-2000s [1].

CJC-1295 DAC was developed to address the main limitation of injectable GH; namely, its short half-life of around seven minutes. DAC, which stands for “Drug Affinity Complex”, is an acetate that’s added to help the CJC-1925 peptide last longer in the body. Studies have shown that CJC-1295 DAC has a half-life of between five and eight days [2].

The other iteration of CJC-1295 that you should know about is actually a peptide blend called CJC-1295 Ipamorelin. Ipamorelin is a substance known as a “secretagogue,” which means that it increases the specificity of CJC-1295. Compared with CJC-1295 DAC, CJC-1295 Ipamorelin is believed to have a stronger impact on the secretion of GH and a lower impact on cortisol and prolactin. CJC-1295 Ipamorelin is also believed to have a stronger effect on fat loss as it doesn’t increase appetite.

These claims, however, are based on anecdotal evidence and not scientific findings.

Next, let’s look at the main benefits and uses of CJC-1295.


CJC-1295

 


CJC-1295 Benefits and Uses

If you’re curious about the benefits and uses of CJC-1295, this is the section for you. CJC-1295 iterations are currently only available as research materials, meaning that their only permitted uses are in vitro testing and laboratory experimentation.

Given CJC-1295’s status as a research chemical, any claims about this peptide's purported benefits have not been confirmed by human clinical trials and any statements you may read online have not been evaluated by the FDA.

In fact, many of CJC-1295’s purported benefits are based on animal studies. For example, an oft-cited study that attributed a “4-fold increase” in GH levels to CJC-1295 was conducted on rats [3]. This indicates that CJC-1295 requires further evaluation and remains very much in the research phase.

So, what are the research-backed benefits of CJC-1295?

Increases Growth Hormone (GH) and Insulin-Like Growth Factor 1 (IGF-1) Levels

Arguably the most important benefit of CJC-1295 is that it stimulates the pituitary gland to release both GH and Insulin-Like Growth Factor 1 (IGF-1). A 2006 double-blind placebo-controlled study [2], found that a single injection of CJC-1295 DAC can:

  • Increase plasma growth hormone concentration 2-10 fold for six days, and
  • Increase plasma IGF-1 concentration 1.5-4 fold for 9-12 days

Based on this evidence, CJC-1295 clearly has a significant impact on GH and IGF-1 levels in the body.

Long Half-Life

The second proven benefit of CJC-1295 is that it has a much longer half-life than GH and other analogues of GH. The aforementioned 2006 study estimated that CJC-1295 DAC has a half-life of 5.8-8.1 days [2]. As this study was based on data from two separate randomized, double-blind, placebo-controlled trials, it offers a clear picture of CJC-1295’s duration in the human body.

Enhanced Athletic Performance

Anecdotal evidence suggests that CJC-1295 is popular among those interested in losing fat and building muscle such as bodybuilders and elite athletes [4]. This is because GH is an anabolic hormone that plays an important role in muscle growth. CJC-1295’s ability to increase levels of GH in the body is one reason why it’s banned by WADA [5]. While this anecdotal evidence strongly indicates that CJC-1295 may enhance athletic performance, there are no scientific studies to support this claim.

Now that we’ve looked at the main research-backed benefits of CJC-1925, let’s look at some of its documented side effects.


CJC-1295 Side Effects

The 2006 study by Teichman et al found that CJC-1295 DAC was generally well-tolerated and produced only mild, temporary side effects in healthy volunteers [2].

At doses of up to 30 micrograms per kilogram (μg/kg), researchers noted that CJC-1295 DAC caused the following side effects:

  • Mild injection site reactions,
  • Itching,
  • Headaches,
  • Pain,
  • Diarrhea,
  • Hypertension, and
  • Induration.

The study’s authors noted that around 70 percent of the volunteers who received CJC-1295 DAC experienced one or more of these side effects and that the severity of the reactions increased with doses over 30 μg/kg.


CJC-1295

 


CJC-1295 Dosage Calculator and Guide

As CJC-1295 is a research chemical, there’s no clinical trial data to support dosing guidelines.

While many subjects are given GH peptides with the belief that it will stimulate their pituitary glands to secrete more endogenous growth hormone, there have been no scientific studies to date on the effects of growth hormone supplementation [6]. However, by looking at published research on CJC-1295, we can begin to extrapolate how CJC-1295 may be dosed in laboratory experiments.

How Do You Administer CJC-1295?

CJC-1295 peptide comes as a liquid suspension and is administered via subcutaneous injection. Common side effects like pain and injection site reactions can be minimized by following the correct injection procedure [7].

What Dose of CJC-1295 Should You Administer?

As CJC-1295 has yet to undergo human clinical trials, there is limited published research into dosing protocol. The 2006 study by Teichman et al involved administering CJC-1295 DAC to test subjects in weekly or biweekly dosages of between 30 μg/kg and 60 μg/kg [2]. For an 80 kg test subject, this would give a weekly dosage range of between 2,400-4,800 μg (2.4 – 4.8 mg).

The study’s authors noted that increases in GH and IGF-I levels produced by CJC-1295 DAC were “dose-dependent,” meaning that in the context of that particular study, higher doses of CJC-1295 produced greater rises in GH and IGF-1 levels than lower doses.

Anecdotal evidence from real world users suggests that doses of CJC-1295 DAC and CJC-1295 Ipamorelin should be limited to 2,000 μg per week [8], regardless of an individual’s bodyweight. The 2,000 μg can be divided into a twice-daily 200 μg injections, or once-daily 400 μg injections, five days per week, with two days off to aid the recovery of the anterior pituitary receptors to recover.

When Should CJC-1295 Be Administered?

Proponents of CJC-1295 have speculated that the best time to administer this peptide is before sleep, at least two hours after dinner. Animal studies have found that dietary glucose (the sugar in food and drinks) can suppress growth hormone levels in rats [9], and Growth hormone levels in humans are known to peak in the late evening, just before bedtime.

When an evening dosing schedule isn’t possible, it has been suggested that CJC-1295 can be taken early in the morning on an empty stomach. This is thought to prevent dietary glucose from interfering with GH levels.

How Often Should CJC-1295 Be Administered?

In terms of published research, we know that CJC-1295 can be taken weekly or biweekly and still increase levels of GH and IGF-1 [2]. However, according to statements from functional medicine experts Lindgren [10], patients are advised to take CJC-1295 Ipamorelin five nights per week. For test subjects on a 2,000 μg/week dosing schedule, this would equate to five 400 μg injections per week. Anecdotal evidence supports this guidance and indicates that CJC-1295 can be taken in twice-daily 200 μg doses [8].

How Long Should CJC-1295 Be Administered?

According to Lindgren, it takes 3-6 months to see an upregulation, or increase, in the overall amount of GH isolates being produced by the pituitary gland. At this point, subjects can either be administered lower doses of the CJC-1295 peptide, or research can discontinue. This is supported by Teichman et al’s findings that after multiple CJC-1295 DAC doses, “mean IGF-I levels remained above baseline for up to 28 days” [2].


Where To Buy CJC-1295 Online? | 2021 Guide

CJC-1295 DAC, CJC-1295 no DAC and CJC-1295 blends are all easy to order online. However because CJC-1295 is not a regulated product, you’ll need to do a little research to find a reputable vendor that can supply high-quality peptides. If you’re looking to buy CJC-1295 peptides for research purposes, our recommended vendor is PeptideSciences.

PeptideSciences

US-based PeptideSciences is the most reliable peptide manufacturer we’ve ever tested. They work in partnership with a range of WHO/GMP and ISO 9001:2008-approved manufacturers to create — in our opinion — the highest-quality CJC-1295 peptide on the market.

Some of the reasons why we rate them so highly are:

Third-party Tested Peptides: PeptideSciences tests every batch of CJC-1295 at an independent lab before listing it for sale [11]. You can check the lab report for the batch you are buying before placing an order. This ensures that you’ll receive only the very best quality CJC-1295.

Low Prices: This vendor offers some of the best discounts in the industry, including a six percent discount when you order five peptides and a nine percent discount when you order ten or more. Overall, PeptideSciences’ prices are incredibly reasonable.

Secure Ordering: Your order is kept safe and secure with SSl technology, offering you the ultimate in convenience.

Fast Worldwide Shipping: PeptideSciences charges a $15 flat shipping rate for fast worldwide shipping. This is waived for US-based customers who order over $200.

PeptideSciences are the best we’ve come across by far, so we highly recommend them!

Buy CJC-1295 from our #1 recommended vendor...


CJC-1295

 


CJC-1295 Dosage | The Verdict?

So what does the evidence say about CJC-1295 dosage?

Well, as CJC-1295 remains a research chemical, there is limited data from human clinical research to tell much about the appropriate dosage. By using available data and anecdotal evidence, we can only theorize how this peptide might be dosed.

Hopefully this guide has given you a useful starting point for calculating your own dosing schedule for research purposes.


References

  1. Albumin_Bioconjugates_Activate_the_GRF_Receptor_on_the_Anterior_Pituitary_in_
    Rats_Identification_of_CJC-1295_as_a_Long_Lasting_GRF_Analog. (2021). Retrieved 26 February 2021, from https://www.researchgate.net/publication/228484039_hGRF1-29-.
  2. Sam L. Teichman, Ann Neale, Betty Lawrence, Catherine Gagnon, Jean-Paul Castaigne, Lawrence A. Frohman, Prolonged Stimulation of Growth Hormone (GH) and Insulin-Like Growth Factor I Secretion by CJC-1295, a Long-Acting Analog of GH-Releasing Hormone, in Healthy Adults, The Journal of Clinical Endocrinology & Metabolism, Volume 91, Issue 3, 1 March 2006, Pages 799–805, https://doi.org/10.1210/jc.2005-1536
  3. Lucie Jetté, Roger Léger, Karen Thibaudeau, Corinne Benquet, Martin Robitaille, Isabelle Pellerin, Véronique Paradis, Pieter van Wyk, Khan Pham, Dominique P. Bridon, Human Growth Hormone-Releasing Factor (hGRF)1–29-Albumin Bioconjugates Activate the GRF Receptor on the Anterior Pituitary in Rats: Identification of CJC-1295 as a Long-Lasting GRF Analog, Endocrinology, Volume 146, Issue 7, 1 July 2005, Pages 3052–3058, https://doi.org/10.1210/en.2004-1286
  4. Henninge J, Pepaj M, Hullstein I, Hemmersbach P. Identification of CJC-1295, a growth-hormone-releasing peptide, in an unknown pharmaceutical preparation. Drug Test Anal. 2010 Nov-Dec;2(11-12):647-50. doi: 10.1002/dta.233. Epub 2010 Dec 10. PMID: 21204297.
  5. What is Prohibited. World Anti-Doping Agency. (2021). Retrieved 26 February 2021, from https://www.wada-ama.org/en/content/what-is-prohibited/prohibited-at-all-times/peptide-hormones-growth-factors-related-substances-and-mimetics.
  6. Macintyre JG. Growth hormone and athletes. Sports Med. 1987 Mar-Apr;4(2):129-42. doi: 10.2165/00007256-198704020-00004. PMID: 3299611.
  7. Usach I, Martinez R, Festini T, Peris JE. Subcutaneous Injection of Drugs: Literature Review of Factors Influencing Pain Sensation at the Injection Site. Adv Ther. 2019 Nov;36(11):2986-2996. doi: 10.1007/s12325-019-01101-6. Epub 2019 Oct 5. PMID: 31587143; PMCID: PMC6822791.
  8. Reddit.com. (2021). Retrieved 13 March 2021, from https://www.reddit.com/r/Peptides/comments/fa9gvl/cjc_1295_dac_and_ipamorelin_
    cycle_newbie/.
  9. Hage M, Kamenický P, Chanson P. Growth Hormone Response to Oral Glucose Load: From Normal to Pathological Conditions. Neuroendocrinology. 2019;108(3):244-255. doi: 10.1159/000497214. Epub 2019 Jan 25. PMID: 30685760.
  10. Regenerative Medicine Promotes Cellular Level Healing. Lindgren.Health. (2021). Retrieved 28 February 2021, from https://lindgren.health/regenerative-medicine.
  11. CJC-1295 DAC 5mg. PeptideSciences.com. (2021). Retrieved 28 February 2021, from https://www.peptidesciences.com/cjc-1295-dac-5mg.

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